Phase 1 Studies to Evaluate the Food Effect and Relative Bioavailability of Tablet and Capsule Formulations of Belumosudil in Healthy Adult Subjects.
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DOI: 10.1002/cpdd.1083
Abstract: Belumosudil is a selective Rho-associated coiled-coil containing protein kinase 2 inhibitor. A capsule formulation was used during early clinical development of belumosudil; it was later replaced by a tablet formulation, which mimicked the capsule's release… read more here.
Keywords: phase studies; food; relative bioavailability; belumosudil ... See more keywords
Absolute Bioavailability, Mass Balance, and Metabolic Profiling Assessment of [14 C]-Belumosudil in Healthy Men: A Phase 1, Open-Label, 2-Part Study.
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DOI: 10.1002/cpdd.1085
Abstract: Belumosudil is a selective Rho-associated coiled-coil containing protein kinase 2 (ROCK2) inhibitor. ROCK2 has been shown to drive proinflammatory response and fibrosis that occurs with chronic graft-versus-host disease; therefore, inhibition of ROCK2 has emerged as… read more here.
Keywords: balance metabolic; absolute bioavailability; part study; belumosudil ... See more keywords
A critical review of belumosudil in adult and pediatric patients with chronic graft-versus-host disease
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DOI: 10.1080/1744666x.2023.2152330
Abstract: ABSTRACT Introduction Chronic graft-versus-host disease (cGVHD) is a complication of allogeneic hematopoietic cell transplantation (allo-HCT) and is the main cause of late non-relapse mortality (NRM). Three new agents are now approved to treat cGVHD, of… read more here.
Keywords: chronic graft; adult pediatric; host disease; versus host ... See more keywords