Synthesis of Bempedoic Acid through Electrochemical Decarboxylation of Dialkylated Malonic Acid
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DOI: 10.1055/a-1482-9822
Abstract: Bempedoic acid is a small-molecule inhibitor of adenosine triphosphate-citrate lyase (ACL) that is effective in the treatment of hypercholesterolemia and hypertension. In this paper, a new, six-step synthesis of bempedoic acid with 42% overall yield… read more here.
Keywords: bempedoic; synthesis bempedoic; decarboxylation dialkylated; electrochemical decarboxylation ... See more keywords
The Disposition and Metabolism of Bempedoic Acid, a Potent Inhibitor of ATP Citrate Lyase, in Healthy Human Subjects
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DOI: 10.1124/dmd.122.001142
Abstract: The disposition and metabolism of bempedoic acid, a selective inhibitor of ATP citrate lyase, were examined in healthy male subjects. After a single administration of [14C] bempedoic acid (240 mg, 113 μCi) oral solution, mean… read more here.
Keywords: bempedoic; bempedoic acid; disposition metabolism;
Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Ldlr−/− Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic Acid
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DOI: 10.1161/atvbaha.116.308963
Abstract: Objective— Bempedoic acid (ETC-1002, 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid) is a novel low-density lipoprotein cholesterol–lowering compound. In animals, bempedoic acid targets the liver where it inhibits cholesterol and fatty acid synthesis through inhibition of ATP-citrate lyase and through… read more here.
Keywords: bempedoic acid; bempedoic; diet induced; treatment ... See more keywords
Mechanism of action and therapeutic use of bempedoic acid in atherosclerosis and metabolic syndrome
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DOI: 10.3389/fcvm.2022.1028355
Abstract: Bempedoic acid is a new cholesterol-lowering drug, which has recently received US FDA and EMA approval. This drug targets lipid and glucose metabolism as well as inflammation via downregulation of ATP-citrate lyase and upregulation of… read more here.
Keywords: clinical trials; metabolic syndrome; bempedoic; mechanism action ... See more keywords