Benchmark dose modelling in regulatory ecotoxicology, a potential tool in pest management.
Sign Up to like & getrecommendations! Published in 2021 at "Pest management science"
DOI: 10.1002/ps.6759
Abstract: The benchmark dose (BMD) methodology has become the recommended approach to derive reference values for risk assessment for several authorities. However, in practice, the BMD approach is not standard use in the risk assessment for… read more here.
Keywords: benchmark dose; approach; bmd; pest management ... See more keywords
Benchmark dose estimation for coke oven emissions based on oxidative damage in Chinese exposed workers.
Sign Up to like & getrecommendations! Published in 2020 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2020.110889
Abstract: Coke oven emissions (COEs) can cause oxidative stress of the body, which in turn induces the occupational lung disease and also increases the risk of other diseases. COEs are the major occupational hazard factors for… read more here.
Keywords: oxidative damage; coke oven; benchmark dose; oven emissions ... See more keywords
Benchmark dose analysis of multiple thyroid toxicity endpoints in ovariectomized rats exposed to propylthiouracil
Sign Up to like & getrecommendations! Published in 2018 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2018.06.013
Abstract: ABSTRACT Benchmark dose (BMD) analysis is generally recognized superior to generate a point of departure (PoD) to conduct risk assessment on environmental toxicants, comparing with the traditionally employed no observed adverse effect level (NOAEL) or… read more here.
Keywords: thyroid toxicity; analysis; benchmark dose; toxicity endpoints ... See more keywords
Benchmark dose modeling of transcriptional data: a systematic approach to identify best practices for study designs used in radiation research
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2022.2110300
Abstract: Abstract Purpose Benchmark dose (BMD) modeling is a method commonly used in chemical toxicology to identify the point of departure (POD) from a dose-response curve linked to a health-related outcome. Recently, its application in the… read more here.
Keywords: bmd; dose; number; radiation ... See more keywords
Evaluating the influences of confounding variables on benchmark dose using a case study in the field of ionizing radiation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2022.2110303
Abstract: Abstract Purpose A vast amount of data regarding the effects of radiation stressors on transcriptional changes has been produced over the past few decades. These data have shown remarkable consistency across platforms and experimental design,… read more here.
Keywords: bmd; confounding variables; radiation; benchmark dose ... See more keywords
Considerations for application of benchmark dose modeling in radiation research: workshop highlights.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of radiation biology"
DOI: 10.1080/09553002.2023.2181998
Abstract: BACKGROUND Exposure to different forms of ionizing radiation occurs in diverse occupational, medical, and environmental settings. Improving the accuracy of the estimated health risks associated with exposure is therefore, essential for protecting the public, particularly… read more here.
Keywords: toxicology; bmd modeling; modeling radiation; radiation ... See more keywords
A benchmark for dose-finding studies with unknown ordering.
Sign Up to like & getrecommendations! Published in 2021 at "Biostatistics"
DOI: 10.1093/biostatistics/kxaa054
Abstract: An important tool to evaluate the performance of a dose-finding design is the nonparametric optimal benchmark that provides an upper bound on the performance of a design under a given scenario. A fundamental assumption of… read more here.
Keywords: finding studies; dose finding; unknown ordering; studies unknown ... See more keywords
A benchmark for dose finding studies with continuous outcomes.
Sign Up to like & getrecommendations! Published in 2018 at "Biostatistics"
DOI: 10.1093/biostatistics/kxy045
Abstract: An important tool to evaluate the performance of any design is an optimal benchmark proposed by O'Quigley and others (2002. Non-parametric optimal design in dose finding studies. Biostatistics3, 51-56) that provides an upper bound on… read more here.
Keywords: finding studies; dose finding; continuous outcomes; outcomes benchmark ... See more keywords
Benchmark dose in the presence of coexposure to melamine and diethylhexyl phthalate and urinary renal injury markers in pregnant women.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental research"
DOI: 10.2139/ssrn.4118344
Abstract: Environmental exposures to mixtures of toxic chemicals have potential interaction effects that may lead to hazard index values exceeding one. However, current regulation levels, such as tolerable daily intake (TDI), are mostly based on experimental… read more here.
Keywords: injury markers; renal injury; melamine; pregnant women ... See more keywords
Fluoride subacute testicular toxicity in Wistar rats: Benchmark dose analysis for the redox parameters, essential elements and DNA damage.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental pollution"
DOI: 10.2139/ssrn.4191341
Abstract: Excessive fluoride (F-) levels in the environment could induce different pathological changes, including comorbidities in reproductive functions. Hence, the aim of the present in vivo study was to explore F- subacute toxicity mechanisms via Benchmark… read more here.
Keywords: parameters essential; damage; dna damage; essential elements ... See more keywords
Guidance on the use of the benchmark dose approach in risk assessment
Sign Up to like & getrecommendations! Published in 2022 at "EFSA Journal"
DOI: 10.2903/j.efsa.2022.7584
Abstract: Abstract The Scientific Committee (SC) reconfirms that the benchmark dose (BMD) approach is a scientifically more advanced method compared to the no‐observed‐adverse‐effect‐level (NOAEL) approach for deriving a Reference Point (RP). The major change compared to… read more here.
Keywords: guidance use; guidance; benchmark dose; bmd approach ... See more keywords