Activated microglia promote invasion and barrier dysfunction of brain endothelial cells via regulating the CXCL13/CXCR5 axis
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DOI: 10.1002/cbin.11832
Abstract: The blood brain barrier (BBB) is a protective border that prevents noxious substances from gaining access to the central nervous system (CNS). CXCL13 is a chemokine from the CXC chemokine family, which has been shown… read more here.
Keywords: barrier dysfunction; invasion barrier; cxcr5; bend cells ... See more keywords
Panax notoginseng saponins suppress lipopolysaccharide‐induced barrier disruption and monocyte adhesion on bEnd.3 cells via the opposite modulation of Nrf2 antioxidant and NF‐κB inflammatory pathways
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DOI: 10.1002/ptr.6488
Abstract: Dysfunction of the blood‐brain barrier (BBB) is a prerequisite for the pathogenesis of many cerebral diseases. Oxidative stress and inflammation are well‐known factors accounting for BBB injury. Panax notoginseng saponins (PNS), a clinical commonly used… read more here.
Keywords: notoginseng saponins; panax notoginseng; nrf2 antioxidant; adhesion bend ... See more keywords
Nrf2 redox signalling in brain endothelial cells adapted to physiological O2: an in vitro model for ischaemia-reperfusion injury in stroke
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DOI: 10.1016/j.freeradbiomed.2018.04.435
Abstract: Sulforaphane (SFN) has been shown to protect against damage sustained following transient ischaemic stroke via activation of the redox-sensitive transcription factor Nrf2. To further understand the protective effects of SFN on the cerebral endothelium, mouse… read more here.
Keywords: vitro model; redox; brain endothelial; bend cells ... See more keywords