Effects of anti‐IL5 biological treatments on blood IgE levels in severe asthmatic patients: A real‐life multicentre study (BIONIGE)
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DOI: 10.1002/clt2.12143
Abstract: Abstract Background Mepolizumab and benralizumab are clinically effective biological treatments for severe eosinophilic asthmatic patients by hampering eosinophilic inflammation. The effects of these compound on the immunoglobulin (Ig)E T2 component are virtually unknown. Objectives To… read more here.
Keywords: asthmatic patients; ige levels; blood; biological treatments ... See more keywords
Real-life effects of benralizumab on airway oscillometry in severe eosinophilic asthma
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DOI: 10.1136/bmjresp-2022-001472
Abstract: Introduction Eosinophil depletion with benralizumab reduces exacerbations and improves disease control and FEV1 in patients with severe eosinophilic asthma. However, few studies have investigated the effect of biologics on small airways dysfunction (SAD) even though… read more here.
Keywords: eosinophilic asthma; real life; asthma; oscillometry ... See more keywords
Relationship between benralizumab exposure and asthma exacerbation rate for patients with severe asthma
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DOI: 10.1183/1393003.congress-2017.pa4697
Abstract: Introduction: Benralizumab is an anti-eosinophil monoclonal antibody targeting human IL-5Rα. In the randomized, controlled Phase III SIROCCO ( Lancet . 2016;388:2115–27) and CALIMA ( Lancet . 2016;388:2128–41) trials, benralizumab 30 mg every 4 weeks and… read more here.
Keywords: patients severe; severe asthma; exposure; aer ... See more keywords
Rapid Benralizumab effectiveness in patients with severe eosinophilic asthma and bronchiectasis
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DOI: 10.1183/13993003.congress-2020.2225
Abstract: Background: Benralizumab reduces eosinophils both in sputum and peripheral blood, oral corticosteroid intake (OCS), improves pulmonary function and asthma control. Association between asthma and bronchiectasis (BE) is quite frequent, particularly in patients with severe asthma.… read more here.
Keywords: patients severe; severe eosinophilic; eosinophilic asthma; benralizumab ... See more keywords
Benralizumab for the treatment of asthma.
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DOI: 10.1358/dot.2017.53.12.2736670
Abstract: Benralizumab is a humanized monoclonal antibody directed at the a subunit of the interleukin-5 receptor (IL-5R) that is under clinical development. The binding of benralizumab with the alpha chain of IL-5R results in inhibition of… read more here.
Keywords: benralizumab treatment; treatment asthma; benralizumab;
Single-Use Autoinjector Functionality And Reliability For At-Home Administration Of Benralizumab For Patients With Severe Asthma: GRECO Trial Results
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DOI: 10.2147/jaa.s224266
Abstract: Purpose Accessorized prefilled syringes (APFS) have demonstrated functionality and reliability for subcutaneous (SC) delivery, including self-administration, of benralizumab 30 mg in the clinic or at home. The multicenter, open-label GRECO study (NCT02918071) assessed functionality and… read more here.
Keywords: administration; home; patients caregivers; functionality reliability ... See more keywords
Real-World Experience with Benralizumab in Patients with Severe Eosinophilic Asthma: A Case Series
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DOI: 10.2147/jaa.s295676
Abstract: Purpose Severe eosinophilic asthma (SEA) is characterized by high eosinophilia, severe symptoms, important comorbidities, frequent exacerbations, and poor asthma control. Benralizumab, targeting the interleukin-5 receptor alpha, proved effective in inducing rapid eosinophil depletion and amelioration… read more here.
Keywords: eosinophilic asthma; severe eosinophilic; case series; asthma ... See more keywords
Effectiveness of Switching to Benralizumab in Severe Refractory Eosinophilic Asthma
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DOI: 10.2147/jaa.s358705
Abstract: Purpose Benralizumab is a monoclonal antibody that targets the α subunit of the IL-5 receptor. Clinical trials have demonstrated the efficacy of this agent with respect to lung function and symptom control in patients with… read more here.
Keywords: eosinophilic asthma; refractory eosinophilic; control; severe refractory ... See more keywords
Long-Term Efficacy and Clinical Remission After Benralizumab Treatment in Patients with Severe Eosinophilic Asthma: A Retrospective Study
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DOI: 10.2147/jaa.s391807
Abstract: Background Few studies on the long-term efficacy of benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, have been conducted for patients with severe eosinophilic asthma (SEA), especially regarding the improvement of pulmonary function and clinical remission… read more here.
Keywords: clinical remission; long term; asthma; benralizumab ... See more keywords