Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting.
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DOI: 10.1021/acs.jmedchem.0c01025
Abstract: HDACs are an attractive therapeutic target for a variety of human diseases. Currently, all four FDA-approved HDAC-targeting drugs are non-selective, pan-HDAC inhibitors, exhibiting adverse side-effects at therapeutic doses. While selective HDAC-inhibition has been proposed to… read more here.
Keywords: conformationally constrained; hdac8; benzanilide scaffolds; scaffolds potent ... See more keywords