A Benzannulation Strategy for Rapid Access to Quinazoline-2,4-diones via Oxidative N-Heterocyclic Carbene Catalysis.
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DOI: 10.1021/acs.orglett.2c00954
Abstract: N-Heterocyclic carbene-catalyzed formal [4+2] benzannulation of enals with suitably substituted pyrimidine-2,4-diones allowing the mild and facile synthesis of functionalized quinazoline-2,4-diones is presented. This oxidative transformation proceeds via the simultaneous generation of dienolates and α,β-unsaturated acylazoliums… read more here.
Keywords: benzannulation strategy; strategy rapid; quinazoline diones; heterocyclic carbene ... See more keywords