Pharmacokinetic properties of enantiomerically pure GluN2B selective NMDA receptor antagonists with 3-benzazepine scaffold.
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DOI: 10.1016/j.jpba.2019.04.032
Abstract: Recently, the eutomers of highly potent GluN2B selective NMDA receptor antagonists with 3-benzazepine scaffold were identified. Herein, pharmacokinetic properties regarding lipophilicity, plasma protein binding (PPB) and metabolism are analyzed. The logD7.4 values of 1.68 for… read more here.
Keywords: benzazepine scaffold; glun2b selective; selective nmda; nmda receptor ... See more keywords