Association of a reactive intermediate derived from 1′,6‐dihydroxy metabolite with benzbromarone‐induced hepatotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.21946
Abstract: Treatment with benzbromarone can be associated with liver injury, but the detailed mechanism remains unknown. Our recent studies demonstrated that benzbromarone was metabolized to 1′,6‐dihydroxybenzbromarone and followed by formation of reactive intermediates that were trapped… read more here.
Keywords: reactive intermediate; intermediate derived; liver injury; benzbromarone ... See more keywords
The Protective Effects of Benzbromarone Against Propofol-Induced Inflammation and Injury in Human Brain Microvascular Endothelial Cells (HBMVECs).
Sign Up to like & getrecommendations! Published in 2021 at "Neurotoxicity research"
DOI: 10.1007/s12640-021-00387-1
Abstract: It has been widely reported that severe neurotoxicity can be induced by the application of propofol, which is closely related to the disruption of the blood-brain barrier (BBB) induced by inflammation and injury in the… read more here.
Keywords: propofol; propofol induced; induced inflammation; brain ... See more keywords
The risk of ischemic cerebrovascular disease associated with benzbromarone use in gout people: A retrospective cohort study in Taiwan
Sign Up to like & getrecommendations! Published in 2023 at "Medicine"
DOI: 10.1097/md.0000000000032779
Abstract: Epidemiological studies have shown that people having hyperuricemia are at increased risk of ischemic cerebrovascular disease. This research aimed to study the relation of ischemic cerebrovascular disease with benzbromarone use among persons with gout-related disorders.… read more here.
Keywords: cerebrovascular disease; group; use; ischemic cerebrovascular ... See more keywords
Benzbromarone inhibition of phasic smooth muscle contractions of mouse urinary bladder
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732696
Abstract: Calcium-activated chloride (ClCa) channels play a key role in generating pacemaker currents responsible for maintaining motility in the phasic smooth muscle of the gastrointestinal tract. These channels may play a similar role in the urinary… read more here.
Keywords: bladder; transient pressure; pressure events; physiology ... See more keywords
Liver failure associated with benzbromarone: A case report and review of the literature
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DOI: 10.12998/wjcc.v7.i13.1717
Abstract: BACKGROUND Benzbromarone is a uricosuric agent that reduces proximal tubular reabsorption of uric acid. Because of hepatotoxicity, it has been withdrawn from the market in Europe. Recently, some benefit-risk assessments of benzbromarone suggest that benzbromarone… read more here.
Keywords: failure associated; liver failure; case; associated benzbromarone ... See more keywords
Alterations of the Gut Microbiome Associated With the Treatment of Hyperuricaemia in Male Rats
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DOI: 10.3389/fmicb.2018.02233
Abstract: Hyperuricaemia is an important risk factor for many diseases including gout, hypertension, and type II diabetes. The gut microbiota is associated with hyperuricaemia and has also been demonstrated to play significant roles in the effects… read more here.
Keywords: male rats; alterations gut; treatment; benzbromarone ... See more keywords
Reduced Incidence of Stroke in Patients with Gout Using Benzbromarone
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DOI: 10.3390/jpm12010028
Abstract: Gout is strongly associated with the incidence of atherosclerotic events, including stroke and myocardial infarction. Considering the increased prevalence of stroke in the population with gout, the aim of this study was to evaluate the… read more here.
Keywords: incidence stroke; benzbromarone; incidence; population gout ... See more keywords
Comparison of Benzbromarone and Allopurinol on Primary Prevention of the First Gout Flare in Asymptomatic Hyperuricemia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12050697
Abstract: Objectives. Whether uric acid-lowering agent use in asymptomatic hyperuricemia can reduce the development of the first gout flare remains unsettled. The goal of the present research was to test the efficacy of benzbromarone and allopurinol… read more here.
Keywords: gout flare; first gout; asymptomatic hyperuricemia; benzbromarone ... See more keywords