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Published in 2020 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520620999200818155031
Abstract: BACKGROUND Cancer is known to be the second significant cause of death worldwide. Chemotherapeutic agents such as platinum-based compounds are frequently used single-handedly or accompanied with additional chemotherapies to treat cancer patients. Chemotherapy-inducedperipheral painful neuropathy…
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Keywords:
benzimidazole derivative;
tolerance;
induced neuropathic;
mice ... See more keywords
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Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119438
Abstract: The bis-benzimidazole derivative (BBM) molecule, consisting of two 2-(2′-hydroxyphenyl) benzimidazole (HBI) halves, has been synthesized and successfully utilized as a ratiometric fluorescence sensor for the sensitive detection of Cu2+ based on enol–keto excited-state intramolecular proton…
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Keywords:
benzimidazole derivative;
state intramolecular;
bis benzimidazole;
excited state ... See more keywords
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Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020836
Abstract: In this study, a kilogram-scale synthesis of a potent TRPV1 antagonist, 1, is described. To synthesize bipyridinyl benzimidazole derivative 1, we have developed a scalable Suzuki–Miyaura reaction capable of providing a key intermediate, 6′-methyl-3-(trifluoromethyl)-2,3′-bipyridine 4,…
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Keywords:
oxidation;
reaction;
trpv1 antagonist;
suzuki miyaura ... See more keywords