Design, synthesis, and biological evaluation of new pyrazino[1,2‐a]benzimidazole derivatives as selective cyclooxygenase (COX‐2) inhibitors
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DOI: 10.1002/ardp.201800265
Abstract: A new class of pyrazino[1,2‐a]benzimidazole derivatives possessing the SO2Me pharmacophore at the para position of the C‐3 phenyl ring was designed, synthesized, and tested for their cyclooxygenase‐2 (COX‐2) inhibitory, anti‐cancer and anti‐platelet aggregation activities. In… read more here.
Keywords: pyrazino benzimidazole; cox; cyclooxygenase cox; benzimidazole derivatives ... See more keywords
Cucurbit[7]uril Inclusion Complexes with Benzimidazole Derivatives: A Computational Study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Solution Chemistry"
DOI: 10.1007/s10953-018-0812-2
Abstract: Molecular dynamics (MD) simulations were carried out to study the host–guest complexation in aqueous solution between cucurbit[7]uril (CB7) and the neutral and protonated forms of benzimidazole derivatives. Complexation occurs via encapsulation of the hydrophobic part… read more here.
Keywords: benzimidazole derivatives; cucurbit uril; study; host guest ... See more keywords
Therapeutic evolution of benzimidazole derivatives in the last quinquennial period.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.12.010
Abstract: Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained considerable attention in the field of contemporary medicinal chemistry. The moiety is of substantial importance because of its wide array of pharmacological activities. This nitrogen… read more here.
Keywords: chemistry; evolution benzimidazole; therapeutic evolution; derivatives last ... See more keywords
Design, synthesis and docking studies of benzimidazole derivatives as potential EGFR inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.04.012
Abstract: In this study, a series of benzimidazoles bearing thiosemicarbazide chain or triazole and thiadiazole rings were designed and synthesized. Crystal and molecular structure of the compound 5c has been characterized by single crystal X-ray crystallographic… read more here.
Keywords: design synthesis; synthesis docking; docking studies; studies benzimidazole ... See more keywords
Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs).
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111881
Abstract: A scaffold hopping strategy converted the known 1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidine core (1 and 2) by cyclization to a fused [6 + 5+6] membered heterocyclic mGluR2 PAM scaffold. Pharmacophore guided structure-activity relationship (SAR) studies resulted in a series of potent… read more here.
Keywords: discovery dihydropyrazino; metabotropic glutamate; dihydropyrazino benzimidazole; mglur2 ... See more keywords
Preparation and evaluation of some benzimidazole derivatives as antioxidants for local base oil
Sign Up to like & getrecommendations! Published in 2017 at "Egyptian Journal of Petroleum"
DOI: 10.1016/j.ejpe.2016.10.001
Abstract: Some benzimidazole derivatives, 2(1-H benzo(d)imidazole-2-y1)thio) N-butyl acetamide Ia, 2(I-H benzo(d)imidazole-2-yl)thio) N-octylacetamid Ib and 2(I-H benzo(d)imidazole-2-yl) thio) N-dodecylactamide Ic were prepared and studied as antioxidants for base stock. The structure of these compounds was elucidated by… read more here.
Keywords: base oil; local base; spectroscopy; benzimidazole derivatives ... See more keywords
Copper(II) acetate structures with benzimidazole derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2018.12.054
Abstract: Abstract The evaluation of 2-phenylbenzimidazole (LI) and 2-(2-iodophenyl)-5-chlorobenzimidazole (LII) as basic ligand precursors in the synthesis of novel copper(II) acetate structures is described. A reaction of Cu(OAc)2 with LI and LII in aqueous alcoholic solution… read more here.
Keywords: structures benzimidazole; spectroscopy; topology; copper acetate ... See more keywords
N,2,6-Trisubstituted 1H-benzimidazole derivatives as a new scaffold of antimicrobial and anticancer agents: design, synthesis, in vitro evaluation, and in silico studies
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DOI: 10.1039/d2ra06667j
Abstract: Compounds containing benzimidazole moiety occupy privileged chemical space for discovering new bioactive substances. In continuation of our recent work, 69 benzimidazole derivatives were designed and synthesized with good to excellent yields of 46–99% using efficient… read more here.
Keywords: vitro; silico; trisubstituted benzimidazole; synthesis ... See more keywords
Design, synthesis, and computational studies of benzimidazole derivatives as new antitubercular agents
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2036241
Abstract: Abstract The increase in the drug-resistant strains of Mycobacterium tuberculosis has led researchers to new drug targets. The development of new compounds that have effective inhibitory properties with the selective vital structure of Mycobacterium tuberculosis… read more here.
Keywords: design synthesis; development; synthesis computational; benzimidazole derivatives ... See more keywords
Detailed Quantum Mechanical Studies on Three Bioactive Benzimidazole Derivatives and Their Raman Enhancement on Adsorption over Graphene Sheets
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DOI: 10.1080/10406638.2020.1852267
Abstract: Benzimidazole derivatives flubendazole (FD1) and similar derivatives, mebendazole (MD2) and ricobendazole (RD3) have been studied by using various computational tools to analyze their geometry and ... read more here.
Keywords: studies three; three bioactive; mechanical studies; quantum mechanical ... See more keywords
The structures of benzimidazole derivatives and their potential as tuberculostatics.
Sign Up to like & getrecommendations! Published in 2018 at "Acta crystallographica. Section C, Structural chemistry"
DOI: 10.1107/s2053229618014675
Abstract: Tuberculosis still remains a very important problem, especially its multidrug resistant varieties (MDR-TB). Among the potential tuberculostatics, there are two benzimidazole derivatives, namely 5,6-dimethyl-2-phenylethylbenzo[d]imidazole (1) and (E)-5,6-dimethyl-2-styryl-1H-benzo[d]imidazole (2) which showed significant tuberculostatic activities, better than… read more here.
Keywords: potential tuberculostatics; structures benzimidazole; chemistry; linker ... See more keywords