A Vaccine against Benzimidazole-Derived New Psychoactive Substances That Are More Potent Than Fentanyl.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01967
Abstract: New psychoactive substance (NPS) opioids have proliferated within the international drug market. While synthetic opioids are traditionally composed of fentanyl analogues, benzimidazole-derived isotonitazene and its derivatives are the current NPS opioids of concern. Hence, in… read more here.
Keywords: nps opioids; vaccine benzimidazole; new psychoactive; benzimidazole derived ... See more keywords
Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01108
Abstract: Son of sevenless homologue 1 (SOS1) is a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAS. In its active form, GTP-bound RAS is responsible for numerous critical cellular processes.… read more here.
Keywords: nucleotide exchange; exchange ras; benzimidazole derived; exchange ... See more keywords
Design, synthesis, biological evaluation and QSAR analysis of novel N-substituted benzimidazole derived carboxamides
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2070910
Abstract: Abstract As a result of our previous research focussed on benzimidazoles, herein we present design, synthesis, QSAR analysis and biological activity of novel N-substituted benzimidazole derived carboxamides. Carboxamides were designed to study the influence of… read more here.
Keywords: design synthesis; qsar analysis; benzimidazole derived; novel substituted ... See more keywords
Benzimidazole-derived compounds designed for different targets of Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2019 at "Current medicinal chemistry"
DOI: 10.2174/0929867326666190124123208
Abstract: Benzimidazole scaffold has been efficiently used for the design of various pharmacologically active molecules. Indeed, there are various drugs, available today, employed for the treatment of different diseases. Although, there is no benzimidazole moiety containing… read more here.
Keywords: alzheimer disease; benzimidazole derived; compounds designed; derived compounds ... See more keywords
Design, Synthesis, and Biological Evaluation of Aromatic Amide-Substituted Benzimidazole-Derived Chalcones. The Effect of Upregulating TP53 Protein Expression
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25051162
Abstract: A series of benzimidazole-derived chalcones containing aromatic amide substituent were designed and synthesized. All of the chalcone compounds were tested for their in vitro antitumor activity against human cancer cell lines (HCT116, HepG2, A549, and… read more here.
Keywords: aromatic amide; benzimidazole derived; tp53 protein; derived chalcones ... See more keywords
Novel Benzimidazole Derived Imine Ligand and Its Co(III) and Cu(II) Complexes as Anticancer Agents: Chemical Synthesis, DFT Studies, In Vitro and In Vivo Biological Investigations
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16010125
Abstract: The emerging interest in the field of coordination chemistry and their biological applications has created a novel impact in the field of chemical biology. With this motivation, in this work we have synthesized a novel… read more here.
Keywords: dft; ligand; benzimidazole derived; derived imine ... See more keywords