Synthesis of Benzimidazole-Fused Medium-Sized N,S -Heterocycles via Palladium-Catalyzed Cyclizations
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DOI: 10.1002/ejoc.201801686
Abstract: The synthesis of unprecedented benzimidazole-fused thiazocines, thiazonines, and thiazecines having an exocyclic double bond is reported. The process consists in an 8-, 9-, or 10-exo-dig cyclocarbopalladation followed by reduction. The scope and limitations were established… read more here.
Keywords: medium sized; fused medium; sized heterocycles; synthesis benzimidazole ... See more keywords
Base-mediated synthesis of benzimidazole-fused 1,4-benzoxazepines via sequential intermolecular epoxide ring-opening/intramolecular SNAr reactions
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DOI: 10.1016/j.tetlet.2020.152491
Abstract: Abstract We have developed a transition-metal-free, practical route to benzimidazole-fused 1,4-benzoxazepines. Operationally, the protocol involves a K2CO3-mediated intermolecular ring opening of terminal epoxides by 2-(2-fluorophenyl)benzimidazole, followed by an intramolecular nucleophilic aromatic substitution (SNAr) reaction of… read more here.
Keywords: fused benzoxazepines; benzimidazole; epoxide ring; snar ... See more keywords