Benzimidazole hybrids as anticancer drugs: An updated review on anticancer properties, structure–activity relationship, and mechanisms of action (2019–2021)
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DOI: 10.1002/ardp.202200051
Abstract: Cancer, characterized by a deregulation of the cell cycle which mainly results in a progressive loss of cellular differentiation and uncontrolled cellular growth, remains a prominent cause of death across the world. Almost all currently… read more here.
Keywords: structure activity; anticancer properties; activity relationship; benzimidazole hybrids ... See more keywords
New 1,3,4‐oxadiazole‐chalcone/benzimidazole hybrids as potent antiproliferative agents
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DOI: 10.1002/ardp.202200357
Abstract: A series of new 1,3,4‐oxadiazole‐chalcone/benzimidazole hybrids 9a–o and 10a–k were designed and synthesized as potential antiproliferative agents. Hybrids 9a–o exhibited remarkable antiproliferative activities on different NCI‐60 cell lines in a single‐dose assay. The antiproliferative activities… read more here.
Keywords: chalcone benzimidazole; antiproliferative agents; new oxadiazole; benzimidazole hybrids ... See more keywords
Synthesis, and spectroscopic and structural characterization of three new styrylquinoline–benzimidazole hybrids
Sign Up to like & getrecommendations! Published in 2022 at "Acta Crystallographica. Section C, Structural Chemistry"
DOI: 10.1107/s2053229622010063
Abstract: Three new 4-styrylquinoline–benzimidazole hybrids have been synthesized in a two-step reaction sequence. The styrylquinoline fragments are all nonplanar and the molecules are linked into two- or three-dimensional arrays by N—H⋯O and C—H⋯π hydrogen bonds. read more here.
Keywords: styrylquinoline benzimidazole; three new; benzimidazole hybrids; new styrylquinoline ... See more keywords
Design, Synthesis, Docking Study, and Antiproliferative Evaluation of Novel Schiff Base–Benzimidazole Hybrids with VEGFR-2 Inhibitory Activity
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DOI: 10.3390/molecules28020481
Abstract: A new series of Schiff–benzimidazole hybrids 3a–o has been designed and synthesized. The structure of the target compounds was proved by different spectroscopic and elemental analysis tools. The target compounds were evaluated for their in… read more here.
Keywords: nci h460; inhibitory activity; activity; benzimidazole hybrids ... See more keywords
Novel 7-Chloro-4-aminoquinoline-benzimidazole Hybrids as Inhibitors of Cancer Cells Growth: Synthesis, Antiproliferative Activity, in Silico ADME Predictions, and Docking
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DOI: 10.3390/molecules28020540
Abstract: In this study, new 7-chloro-4-aminoquinoline-benzimidazole compounds were synthesized and characterized by NMR, MS, and elemental analysis. These novel hybrids differ in the type of linker and in the substituent on the benzimidazole moiety. Their antiproliferative… read more here.
Keywords: chloro aminoquinoline; aminoquinoline benzimidazole; adme; activity ... See more keywords