New Benzimidazole-, 1,2,4-Triazole-, and 1,3,5-Triazine-Based Derivatives as Potential EGFRWT and EGFRT790M Inhibitors: Microwave-Assisted Synthesis, Anticancer Evaluation, and Molecular Docking Study
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DOI: 10.1021/acsomega.1c06836
Abstract: A new series of benzimidazole, 1,2,4-triazole, and 1,3,5-triazine derivatives were designed and synthesized using a microwave irradiation synthetic approach utilizing 2-phenylacetyl isothiocyanate (1) as a key starting material. All the new analogues were evaluated as… read more here.
Keywords: egfrwt egfrt790m; benzimidazole triazole; triazole triazine; egfrt790m inhibitors ... See more keywords
Synthesis of Benzimidazole-1,2,4-triazole Derivatives as Potential Antifungal Agents Targeting 14α-Demethylase
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DOI: 10.1021/acsomega.2c07755
Abstract: Invasive fungal infections (IFIs) are increasing as major infectious diseases around the world, and the limited efficacy of existing medications has resulted in substantial morbidity and death in patients due to the lack of effective… read more here.
Keywords: benzimidazole triazole; triazole derivatives; targeting demethylase; synthesis benzimidazole ... See more keywords
Water-Assisted Self-Aggregation of Benzimidazole and Triazole Adducts
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DOI: 10.1021/acsomega.8b02688
Abstract: The manuscript revolves around an interesting observation of solidification of a solution of N-((1-((1-ethyl-1H-benzo[d]imidazol-2-yl)methyl)-1H-1,2,3-triazole-4-yl)methyl)aniline (A6) in the NMR tube after around 12 h. Real-time images showed fibrillar and spherulitic growth with tip branching and side… read more here.
Keywords: benzimidazole triazole; water assisted; self aggregation;
Design, synthesis, ADME prediction and pharmacological evaluation of novel benzimidazole-1,2,3-triazole-sulfonamide hybrids as antimicrobial and antiproliferative agents
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DOI: 10.1186/s13065-018-0479-1
Abstract: BackgroundNitrogen heterocyclic rings and sulfonamides have attracted attention of several researchers.ResultsA series of regioselective imidazole-based mono- and bis-1,4-disubstituted-1,2,3-triazole-sulfonamide conjugates 4a–f and 6a–f were designed and synthesized. The first step in the synthesis was a regioselective… read more here.
Keywords: antimicrobial antiproliferative; sulfonamide hybrids; evaluation; benzimidazole triazole ... See more keywords