Synthesis of 1-benzyl-1H-benzimidazoles as galectin-1 mediated anticancer agents.
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DOI: 10.1016/j.bioorg.2019.103016
Abstract: In our pursuit to develop novel non-carbohydrate small molecule Galectin-1 Inhibitors, we have designed a series of 1-benzyl-1H-benzimidazole derivatives and demonstrated their anticancer activity. The compound 6g, 4-(1-benzyl-5-chloro-1H-benzo[d]imidazol-2-yl)-N-(4-hydroxyphenyl) benzamide was found to be most potent… read more here.
Keywords: mediated anticancer; benzyl; benzyl benzimidazoles; benzimidazoles galectin ... See more keywords