LEGO‐Inspired Drug Design: Unveiling a Class of Benzo[d]thiazoles Containing a 3,4‐Dihydroxyphenyl Moiety as Plasma Membrane H+‐ATPase Inhibitors
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DOI: 10.1002/cmdc.201700635
Abstract: The fungal plasma membrane H+‐ATPase (Pma1p) is a potential target for the discovery of new antifungal agents. Surprisingly, no structure–activity relationship studies for small molecules targeting Pma1p have been reported. Herein, we disclose a LEGO‐inspired… read more here.
Keywords: benzo; dihydroxyphenyl; plasma membrane; membrane atpase ... See more keywords
New Insight into Dearomatization and Decarbonylation of Antitubercular 4H‐Benzo[e][1,3]thiazinones: Stable 5H‐ and 7H‐Benzo[e][1,3]thiazines
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DOI: 10.1002/cmdc.202200021
Abstract: 8‐Nitro‐4H‐benzo[e][1,3]thiazinones (BTZs) are potent in vitro antimycobacterial agents. New chemical transformations, viz. dearomatization and decarbonylation, of two BTZs and their influence on the compounds’ antimycobacterial properties are described. Reactions of 8‐nitro‐2‐(piperidin‐1‐yl)‐6‐(trifluoromethyl)‐4H‐benzo[e][1,3]thiazin‐4‐one and the clinical drug candidate… read more here.
Keywords: benzo thiazines; benzo; dearomatization decarbonylation; benzo thiazinones ... See more keywords
Synthesis of tricyclic and tetracyclic benzo[6,7]cycloheptane derivatives linked morpholine moiety as CDK2 inhibitors.
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DOI: 10.1002/ddr.22074
Abstract: With the aim of developing cyclin-dependent kinase 2 (CDK2) inhibitors with strong antibreast cancer efficacy, new tricyclic and tetracyclic benzo[6,7]cycloheptane derivatives were synthesized. The newly synthesized tri- and tetracyclic derivatives were achieved from the reaction… read more here.
Keywords: cycloheptane derivatives; tricyclic tetracyclic; tetracyclic benzo; benzo cycloheptane ... See more keywords
An Efficient Synthesis of Pyrrolo[1,2‐a] or Pyrido[1,2‐a]benzo[4,5]imidazo[1,2‐c]quinazoline Derivatives in Ionic Liquids Catalyzed by Iodine
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2967
Abstract: 2-(1H-benzo[d]imidazol-2-yl)anilines reacted with haloketones including 5-chloropentan-2-one and 6-chlorohexan-2-one catalyzed by iodine, giving benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazoline and 6H-benzo[4,5]imidazo[1,2-c]pyrido[1,2-a]quinazoline derivatives, respectively. This domino-type reaction formed two new heterocycles and three new covalent bonds in one-pot procedure and provided a… read more here.
Keywords: benzo; benzo imidazo; quinazoline derivatives; catalyzed iodine ... See more keywords
A Convenient and Green Synthetic Approach for Benzo[a]pyrano[2,3-c]phenazines via Supramolecular Catalysis
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DOI: 10.1007/s10562-019-03057-2
Abstract: A pragmatic and swift method for the synthesis of Benzo[a]pyrano[2,3-c]phenazine derivatives via one pot, multicomponent strategy by employing β-cyclodextrin in EtOH:H2O (1:1) solvent at 70 °C has been documented here. Utilization of supramolecular catalyst β-cyclodextrin… read more here.
Keywords: benzo; green synthetic; catalysis; benzo pyrano ... See more keywords
Synthesis of N-substituted imidazo[4,5-e]benzo[1,2-c;3,4-c’]difuroxans
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DOI: 10.1007/s11172-017-1991-5
Abstract: N-Substituted imidazo[4,5-e]benzo[1,2-c;3,4-c’]difuroxans were synthesized by phase-transfer catalyzed alkylation of imidazo[4,5-e]benzo[1,2-c;3,4-c’]difuroxan salts with various alkylating agents. Acid hydrolysis of N-(ethoxycarbonylmethyl)imidazo[4,5-e]benzo-[1,2-c;3,4-c’]difuroxans gives the corresponding carboxylic acids. Structures of the synthesized compounds were confirmed by NMR spectroscopy, high… read more here.
Keywords: benzo difuroxans; benzo; imidazo benzo; synthesis substituted ... See more keywords
Theophylline as a new and green catalyst for the one-pot synthesis of spiro[benzo[a]pyrano[2,3-c]phenazine] and benzo[a]pyrano[2,3-c]phenazine derivatives under solvent-free conditions
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DOI: 10.1016/j.cclet.2016.09.016
Abstract: A green, convenient, high yielding and one-pot procedure for the synthesis of novel spiro[benzo[a]pyrano[2,3-c]phenazine] derivatives by domino multi-component condensation reaction between 2-hydroxynaphthalene-1,4-dione, benzene-1,2-diamines, ninhydrine, and malononitrile in the presence of a catalytic amount of 1,3-dimethyl-7H-purine-2,6-dione… read more here.
Keywords: benzo; pyrano phenazine; one pot; benzo pyrano ... See more keywords
Selective C-C bonds formation, N-alkylation and benzo[d]imidazoles synthesis by a recyclable zinc composite
Sign Up to like & getrecommendations! Published in 2021 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2021.06.060
Abstract: Abstract Earth abundant metals are much less expensive, promising, valuable metals and could be served as catalysts for the borrowing hydrogen reaction, dehydrogenation and heterocycles synthesis, instead of noble metals. The uniformly dispersed zinc composites… read more here.
Keywords: alkylation; benzo; bonds formation; selective bonds ... See more keywords
Mini-bioreactors with immobilized microalgae for the removal of benzo(a)anthracene and benzo(a)pyrene from water
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DOI: 10.1016/j.ecoleng.2017.06.059
Abstract: Abstract Polycyclic aromatic hydrocarbons (PAHs), especially those having four or more rings, are abundant and toxic environmental contaminants that are highly persistent and difficult to remove from contaminated ecosystems. Bioreactors with microalgae have been used… read more here.
Keywords: anthracene benzo; mini bioreactors; benzo; removal ... See more keywords
Removal of polycyclic aromatic hydrocarbons from water by magnetic activated carbon nanocomposite from green tea waste.
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DOI: 10.1016/j.jhazmat.2021.125701
Abstract: This study aims to synthesize a magnetic activated carbon nanocomposite from green tea leaf waste (MNPs-GTAC) for evaluation of adsorption efficiency of 4 priority polycyclic aromatic hydrocarbons (PAHs). MNPs-GTAC contained spherically-shaped MNPs with cubic spinel… read more here.
Keywords: green tea; magnetic activated; benzo; activated carbon ... See more keywords
Crystal structure and spectral properties of vitamin K3 based nitrobenzo[a]phenoxazines
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DOI: 10.1016/j.molstruc.2017.07.091
Abstract: Abstract Benzo[ a ]phenoxazines are the planar polycyclic fluorescent compounds, find a variety of applications in biological sciences and are of growing interest. In the present work we synthesized heterocyclic aromatic fluorescent benzo[ a ]phenoxazines… read more here.
Keywords: crystal structure; structure spectral; spectral properties; benzo ... See more keywords