An Efficient Synthesis of Pyrrolo[1,2‐a] or Pyrido[1,2‐a]benzo[4,5]imidazo[1,2‐c]quinazoline Derivatives in Ionic Liquids Catalyzed by Iodine
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2967
Abstract: 2-(1H-benzo[d]imidazol-2-yl)anilines reacted with haloketones including 5-chloropentan-2-one and 6-chlorohexan-2-one catalyzed by iodine, giving benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazoline and 6H-benzo[4,5]imidazo[1,2-c]pyrido[1,2-a]quinazoline derivatives, respectively. This domino-type reaction formed two new heterocycles and three new covalent bonds in one-pot procedure and provided a… read more here.
Keywords: benzo; benzo imidazo; quinazoline derivatives; catalyzed iodine ... See more keywords
Construction of benzo[d]imidazo[2,1-b]thiazole derivatives via a simple multi-component domino cyclization
Sign Up to like & getrecommendations! Published in 2017 at "Research on Chemical Intermediates"
DOI: 10.1007/s11164-017-3123-0
Abstract: An operationally simple and highly efficient one-pot multi-component domino cyclization for the preparation of benzo[d]imidazo[2,1-b]thiazole derivatives from 2-amine-benzo[d]thiazoles, 2-oxoaldehyde and cyclic 1,3-dicarbonyl compounds under microwave irradiation has been developed in this work. Formation of the… read more here.
Keywords: imidazo thiazole; domino cyclization; component domino; multi component ... See more keywords
One-pot synthesis of benzo[4,5]imidazo[1,2-c]quinazolin-6(5H)-ones under catalyst-free conditions and their X-ray crystallographic studies
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.130037
Abstract: Abstract We have developed a perceptive and facile approach for the synthesis of new benzo[4,5]imidazo[1,2-c]quinazolin-6(5H)-one derivatives by one-pot two component condensation involving various o-phenylenediamines and substituted isatins in aqueous ethanol at 80 °C. In this methodology,… read more here.
Keywords: imidazo quinazolin; benzo imidazo; quinazolin ones;
Fe3O4@TiO2@ILs-ZIF-8 Nanocomposite: A Robust Catalyst for the Synthesis of Benzo[4,5]imidazo[1,2-a]pyrimidines
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.130298
Abstract: Abstract Zeolitic imidazolate frameworks (prototype system ZIF-8) supported on the Fe3O4@TiO2@ILs magnetic nanostructure (Fe3O4@TiO2@ILs-ZIF-8) was first synthesized and it showed high catalytic activity for the one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives. The multi-component reactions of various… read more here.
Keywords: benzo imidazo; tio2 ils; fe3o4 tio2; ils zif ... See more keywords
Discovery of Novel Benzo[4,5]imidazo[1,2-a]pyrazin-1-amine-3-amide-one Derivatives as Anticancer Human A2A Adenosine Receptor Antagonists.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00101
Abstract: The blockade of A2A adenosine receptor (A2AAR) activates immunostimulatory response through regulating signaling in tumor microenvironment. Thus, A2AAR has been proposed as a promising target for cancer immunotherapy. In this work, we designed a new… read more here.
Keywords: a2a adenosine; adenosine; benzo imidazo; pyrazin amine ... See more keywords
CuI nanoparticle-catalyzed synthesis of tetracyclic benzo[e]benzo[4,5]imidazo[1,2-c][1,3]thiazin-6-imine heterocycles by SNAr-type C–S, C–N bond formation from isothiocyanatobenzenes and benzimidazoles
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra02552e
Abstract: In this paper, a simple and practical synthesis of benzo[e]benzo[4,5]imidazo[1,2-c][1,3]thiazin-6-imine tetracyclic heterocycles via a CuI nanoparticle-catalyzed intramolecular C(sp2)–S coupling reaction is presented. This strategy provides a straightforward method for synthesizing analogs of the anti-HIV drug… read more here.
Keywords: benzo; benzo imidazo; imidazo thiazin; benzo benzo ... See more keywords
Design, synthesis and biological evaluation of benzo-[d]-imidazo-[2,1-b]-thiazole and imidazo-[2,1-b]-thiazole carboxamide triazole derivatives as antimycobacterial agents
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DOI: 10.1039/d2ra03318f
Abstract: In the search for new anti-mycobacterial agents, we revealed the importance of imidazo-[2,1-b]-thiazole and benzo-[d]-imidazo-[2,1-b]-thiazole carboxamide derivatives. We designed, in silico ADMET predicted and synthesized four series of novel imidazo-[2,1-b]-thiazole and benzo-[d]-imidazo-[2,1-b]-thiazole carboxamide analogues in… read more here.
Keywords: imidazo thiazole; thiazole carboxamide; benzo imidazo;
Synthesis of Benzo[4,5]imidazo[1,2-a]naphthyridine and Benzo[4,5]imidazo[2,1-a]isoquinoline Derivatives Catalyzed by CuI/L-Proline
Sign Up to like & getrecommendations! Published in 2020 at "Polycyclic Aromatic Compounds"
DOI: 10.1080/10406638.2018.1450270
Abstract: GRAPHICAL ABSTRACT ABSTRACT The benzo[4,5]imidazo[1,2-a]naphthyridines and benzo[4,5]imidazo[2,1-a]isoq-uino lines were obtained via a one-pot domino reaction of 2-(2-bromophenyl)-1H-benzo[d]imidazoles and cyclic 1,3-dicarbonyl compounds in good yields. This copper-catalyzed procedure provided an efficient method for the synthesis of… read more here.
Keywords: benzo; synthesis benzo; benzo imidazo; imidazo naphthyridine ... See more keywords
4-(Aryl)-Benzo[4,5]imidazo[1,2-a]pyrimidine-3-Carbonitrile-Based Fluorophores: Povarov Reaction-Based Synthesis, Photophysical Studies, and DFT Calculations
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27228029
Abstract: A series of novel 4-(aryl)-benzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitriles were obtained through the Povarov (aza-Diels–Alder) and oxidation reactions, starting from benzimidazole-2-arylimines. Based on the literature data and X-ray diffraction analysis, it was discovered that during the Povarov reaction, [1,3]… read more here.
Keywords: povarov reaction; spectroscopy; aryl benzo; benzo imidazo ... See more keywords
Efficient Synthesis of 1H-Benzo[4,5]imidazo[1,2-c][1,3]oxazin-1-one Derivatives Using Ag2CO3/TFA-Catalyzed 6-endo-dig Cyclization: Reaction Scope and Mechanistic Study
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28052403
Abstract: A small library of 1H-benzo[4,5]imidazo[1,2-c][1,3]oxazin-1-one derivatives was prepared in good to excellent yields, involving a Ag2CO3/TFA-catalyzed intramolecular oxacyclization of N-Boc-2-alkynylbenzimidazole substrates. In all experiments, the 6-endo-dig cyclization was exclusively achieved since the possible 5-exo-dig heterocycle… read more here.
Keywords: ag2co3 tfa; dig; benzo imidazo; endo dig ... See more keywords