Synthesis and evaluation of 2‐aryl‐1H‐benzo[d]imidazole derivatives as potential microtubule targeting agents
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21909
Abstract: Microtubule targeting agents (MTAs) are the potential drug candidates for anticancer drug discovery. Disrupting the microtubule formation or inhibiting the de‐polymerization process by a synthetic molecule can lead to an excellent anticancer drug candidate. Here,… read more here.
Keywords: microtubule targeting; benzo imidazole; imidazole derivatives; microtubule ... See more keywords
Discovery of the PARP (poly ADP-ribose polymerase) inhibitor 2-(1-(4,4-difluorocyclohexyl)piperidin-4-yl)-1H-benzo[d]imidazole-4-carboxamide for the treatment of cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105026
Abstract: In this work, two series of cyclic amine-containing benzimidazole carboxamide derivatives were designed and synthesized as potent anticancer agents. PARP1/2 inhibitory activity assays indicated that most of the compounds showed significant activity. The in vitro… read more here.
Keywords: piperidin benzo; imidazole carboxamide; carboxamide; benzo imidazole ... See more keywords
Discovery of new 2-phenyl-1H-benzo[d]imidazole core-based potent α-glucosidase inhibitors: Synthesis, kinetic study, molecular docking, and in vivo anti-hyperglycemic evaluation.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105423
Abstract: In the present study, a series of 2-phenyl-1H-benzo[d]imidazole-based α-glucosidase inhibitors were synthesized and evaluated for their in vitro and in vivo anti-diabetic potential. Screening of an in-house library revealed a moderated α-glucosidase inhibitor, 6a with… read more here.
Keywords: phenyl benzo; vivo anti; glucosidase inhibitors; study ... See more keywords
Benzo[d]imidazole-functionalized triazatruxenes as the emitting materials for solution-processed non-doped OLEDs
Sign Up to like & getrecommendations! Published in 2021 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2021.109165
Abstract: Abstract Two benzo[d]imidazole/triazatruxene hybrid compounds, 5,10,15-tributyl-2,7,12-tris(4-(1-phenyl-1H-benzo[d]imidazole-2-yl)phenyl)-10,15-dihydro-5H-diindolo[3,2-a:3′,2′-c]carbazole (2,7,12-TBI-TAT) and 5,10,15-tributyl-3,8,13-tris(4-(1-phenyl-1H-benzo[d]imidazole-2-yl)phenyl)-10,15-dihydro-5H-diindolo[3,2-a:3′,2′-c]carbazole (3,8,13-TBI-TAT), were synthesized by the introduction of three benzo[d]imidazole (BI) moieties at 2-, 7-, 12-positions and 3-, 8-, 13-positions of the alkylated triazatruxene (TAT) core, respectively.… read more here.
Keywords: tat; doped oleds; phenyl; non doped ... See more keywords
Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112108
Abstract: Aurora A kinase, a member of the Aurora kinase family, is frequently overexpressed in various human cancers. In addition, Overexpression of Aurora A kinase is associated with drug resistance and poor prognosis in many cancers… read more here.
Keywords: amino benzo; kinase; imidazole quinazolin; benzo imidazole ... See more keywords
Seven new Zn(II)/Cd(II) coordination polymers with 2-(hydroxymethyl)-1H-benzo[d]imidazole-5-carboxylic acid: Synthesis, structures and properties
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Solid State Chemistry"
DOI: 10.1016/j.jssc.2017.04.039
Abstract: Abstract Using a new simi-rigid multitopic ligand 2-(hydroxymethyl)-1H-benzo[d]imidazole-5-carboxylic acid (H2L), seven new coordination polymers [Zn3(L)2(μ2-OH)2]n (1), {[Zn2(HL)2(H2O)2]·SiF6}n (2), [Zn(HL)(SCN)]n (3), {[Zn2(HL)2(SO4)]·(4,4′-bpy)}n (4) [4,4′-bpy =4,4′-bipyridine], {[Zn(HL)2]·2H2O}n (5), {[Cd(HL)2]·2H2O}n (6) and [Cd2(HL)2(H2O)2(SO4)]n (7) have been successfully obtained… read more here.
Keywords: hydroxymethyl benzo; imidazole carboxylic; carboxylic acid; benzo imidazole ... See more keywords
2-(hydroxymethyl)-1H-benzo[d]imidazole-5-carboxylic acid as linker for Co(II)/Ni(II)/Cu(II) coordination polymers: Synthesis, structures and properties
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Solid State Chemistry"
DOI: 10.1016/j.jssc.2017.12.007
Abstract: Abstract We report the synthesis and characterization of five transition metal coordination polymers (CPs) based on M(II) (M: Co, Ni and Cu), 2-(hydroxymethyl)-1 H -benzo[ d ]imidazole-5-carboxylic acid (H 2 L ) ligand. They are… read more here.
Keywords: coordination; hydroxymethyl benzo; imidazole carboxylic; carboxylic acid ... See more keywords
Structural analysis of intramolecular 1,5-type O⋯O and S⋯O interactions in diethyl 2-oxo and diethyl 2-thioxo-1H benzo[d]imidazole-1,3(2H)-dicarboxylate: Experimental and theoretical study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.127929
Abstract: Abstract Four compounds derived from 2-hydroxy and 2-mercaptobenzimidazole were synthesized and characterized by FT-IR spectroscopy, nuclear magnetic resonance and elemental analysis. Two of the resulting compounds –diethyl 2-oxo-1H benzo[d]imidazole-1,3(2H)-dicarboxylate and diethyl 2-thioxo-1H benzo[d]imidazole-1,3(2H)-dicarboxylate– were crystallized… read more here.
Keywords: diethyl oxo; analysis; benzo imidazole; imidazole dicarboxylate ... See more keywords
Synthesis, Characterization, and DFT-Based Electronic and Nonlinear Optical Properties of Methyl 1-(arylsulfonyl)-2-aryl-1H-benzo[d]imidazole-6-carboxylates
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02805
Abstract: Herein, a series of N-1-sulfonyl substituted derivatives of 2-substituted benzimidazoles (2a–2e) were designed and synthesized via structural tailoring of the acceptor part of donor−π–acceptor schemes, and their nonlinear optic (NLO) characteristics were reported. The structures… read more here.
Keywords: synthesis characterization; dft; characterization dft; benzo imidazole ... See more keywords
Novel 5-(Arylideneamino)-1H-Benzo[d]imidazole-2-thiols as Potent Anti-Diabetic Agents: Synthesis, In Vitro α-Glucosidase Inhibition, and Molecular Docking Studies
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03854
Abstract: A novel series of multifunctional benzimidazoles has been reported as potent inhibitors of α-glucosidase. The procedure relies on the synthesis of 5-amino-1H-benzo[d]imidazole-2-thiol 5 via the multistep reaction through 2-nitroaniline 1, benzene-1,2-diamine 2, 1H-benzo[d]imidazole-2-thiol 3, and… read more here.
Keywords: arylideneamino benzo; ic50; ic50 ic50; imidazole thiols ... See more keywords
Assembly of Fluorinated Benzodiazepines via Rh(III)-Catalysed [5+2] Annulation of N-Benzo[d]imidazole Indolines with 2,2-Difluorovinyl Tosylate
Sign Up to like & getrecommendations! Published in 2023 at "New Journal of Chemistry"
DOI: 10.1039/d3nj01544k
Abstract: Herein, we have realized an efficient and solvent-tunable Rh(III)-catalyzed [5+2] annulation of N-benzo[d]imidazole indolines with 2,2-difluorovinyl tosylate that presented an unusual 1,2-regioselectivity for the chemodivergent construction of monofluorinated and gem-difluorinated... read more here.
Keywords: imidazole indolines; indolines difluorovinyl; annulation benzo; benzo imidazole ... See more keywords