Synthesis and evaluation of 2‐aryl‐1H‐benzo[d]imidazole derivatives as potential microtubule targeting agents
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21909
Abstract: Microtubule targeting agents (MTAs) are the potential drug candidates for anticancer drug discovery. Disrupting the microtubule formation or inhibiting the de‐polymerization process by a synthetic molecule can lead to an excellent anticancer drug candidate. Here,… read more here.
Keywords: microtubule targeting; benzo imidazole; imidazole derivatives; microtubule ... See more keywords
Theoretical exploration on excited state behaviors for 2‐(1H‐benzo[d]imidazole‐2‐yl)‐6‐(benzo[d]‐thiazol‐2‐yl)‐4‐bromophenol in nonpolar and polar solvents
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the Chinese Chemical Society"
DOI: 10.1002/jccs.202400328
Abstract: Given the potential significance of novel organic fluorophores with potential dual‐way proton transfer (PT) reaction channels, in this work we mainly focus on probing into the excited state behaviors for the novel 2‐(1H‐benzo[d]imidazole‐2‐yl)‐6‐(benzo[d]‐thiazol‐2‐yl)‐4‐bromophenol (BIBTB) fluorophore.… read more here.
Keywords: excited state; imidazole benzo; polar solvents; benzo imidazole ... See more keywords
Discovery of the PARP (poly ADP-ribose polymerase) inhibitor 2-(1-(4,4-difluorocyclohexyl)piperidin-4-yl)-1H-benzo[d]imidazole-4-carboxamide for the treatment of cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105026
Abstract: In this work, two series of cyclic amine-containing benzimidazole carboxamide derivatives were designed and synthesized as potent anticancer agents. PARP1/2 inhibitory activity assays indicated that most of the compounds showed significant activity. The in vitro… read more here.
Keywords: piperidin benzo; imidazole carboxamide; carboxamide; benzo imidazole ... See more keywords
Discovery of new 2-phenyl-1H-benzo[d]imidazole core-based potent α-glucosidase inhibitors: Synthesis, kinetic study, molecular docking, and in vivo anti-hyperglycemic evaluation.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105423
Abstract: In the present study, a series of 2-phenyl-1H-benzo[d]imidazole-based α-glucosidase inhibitors were synthesized and evaluated for their in vitro and in vivo anti-diabetic potential. Screening of an in-house library revealed a moderated α-glucosidase inhibitor, 6a with… read more here.
Keywords: phenyl benzo; vivo anti; glucosidase inhibitors; study ... See more keywords
Benzo[d]imidazole-functionalized triazatruxenes as the emitting materials for solution-processed non-doped OLEDs
Sign Up to like & getrecommendations! Published in 2021 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2021.109165
Abstract: Abstract Two benzo[d]imidazole/triazatruxene hybrid compounds, 5,10,15-tributyl-2,7,12-tris(4-(1-phenyl-1H-benzo[d]imidazole-2-yl)phenyl)-10,15-dihydro-5H-diindolo[3,2-a:3′,2′-c]carbazole (2,7,12-TBI-TAT) and 5,10,15-tributyl-3,8,13-tris(4-(1-phenyl-1H-benzo[d]imidazole-2-yl)phenyl)-10,15-dihydro-5H-diindolo[3,2-a:3′,2′-c]carbazole (3,8,13-TBI-TAT), were synthesized by the introduction of three benzo[d]imidazole (BI) moieties at 2-, 7-, 12-positions and 3-, 8-, 13-positions of the alkylated triazatruxene (TAT) core, respectively.… read more here.
Keywords: tat; doped oleds; phenyl; non doped ... See more keywords
Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112108
Abstract: Aurora A kinase, a member of the Aurora kinase family, is frequently overexpressed in various human cancers. In addition, Overexpression of Aurora A kinase is associated with drug resistance and poor prognosis in many cancers… read more here.
Keywords: amino benzo; kinase; imidazole quinazolin; benzo imidazole ... See more keywords
Seven new Zn(II)/Cd(II) coordination polymers with 2-(hydroxymethyl)-1H-benzo[d]imidazole-5-carboxylic acid: Synthesis, structures and properties
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Solid State Chemistry"
DOI: 10.1016/j.jssc.2017.04.039
Abstract: Abstract Using a new simi-rigid multitopic ligand 2-(hydroxymethyl)-1H-benzo[d]imidazole-5-carboxylic acid (H2L), seven new coordination polymers [Zn3(L)2(μ2-OH)2]n (1), {[Zn2(HL)2(H2O)2]·SiF6}n (2), [Zn(HL)(SCN)]n (3), {[Zn2(HL)2(SO4)]·(4,4′-bpy)}n (4) [4,4′-bpy =4,4′-bipyridine], {[Zn(HL)2]·2H2O}n (5), {[Cd(HL)2]·2H2O}n (6) and [Cd2(HL)2(H2O)2(SO4)]n (7) have been successfully obtained… read more here.
Keywords: hydroxymethyl benzo; imidazole carboxylic; carboxylic acid; benzo imidazole ... See more keywords
2-(hydroxymethyl)-1H-benzo[d]imidazole-5-carboxylic acid as linker for Co(II)/Ni(II)/Cu(II) coordination polymers: Synthesis, structures and properties
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Solid State Chemistry"
DOI: 10.1016/j.jssc.2017.12.007
Abstract: Abstract We report the synthesis and characterization of five transition metal coordination polymers (CPs) based on M(II) (M: Co, Ni and Cu), 2-(hydroxymethyl)-1 H -benzo[ d ]imidazole-5-carboxylic acid (H 2 L ) ligand. They are… read more here.
Keywords: coordination; hydroxymethyl benzo; imidazole carboxylic; carboxylic acid ... See more keywords
Structural analysis of intramolecular 1,5-type O⋯O and S⋯O interactions in diethyl 2-oxo and diethyl 2-thioxo-1H benzo[d]imidazole-1,3(2H)-dicarboxylate: Experimental and theoretical study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.127929
Abstract: Abstract Four compounds derived from 2-hydroxy and 2-mercaptobenzimidazole were synthesized and characterized by FT-IR spectroscopy, nuclear magnetic resonance and elemental analysis. Two of the resulting compounds –diethyl 2-oxo-1H benzo[d]imidazole-1,3(2H)-dicarboxylate and diethyl 2-thioxo-1H benzo[d]imidazole-1,3(2H)-dicarboxylate– were crystallized… read more here.
Keywords: diethyl oxo; analysis; benzo imidazole; imidazole dicarboxylate ... See more keywords
Synthesis, Characterization, and DFT-Based Electronic and Nonlinear Optical Properties of Methyl 1-(arylsulfonyl)-2-aryl-1H-benzo[d]imidazole-6-carboxylates
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02805
Abstract: Herein, a series of N-1-sulfonyl substituted derivatives of 2-substituted benzimidazoles (2a–2e) were designed and synthesized via structural tailoring of the acceptor part of donor−π–acceptor schemes, and their nonlinear optic (NLO) characteristics were reported. The structures… read more here.
Keywords: synthesis characterization; dft; characterization dft; benzo imidazole ... See more keywords
Novel 5-(Arylideneamino)-1H-Benzo[d]imidazole-2-thiols as Potent Anti-Diabetic Agents: Synthesis, In Vitro α-Glucosidase Inhibition, and Molecular Docking Studies
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03854
Abstract: A novel series of multifunctional benzimidazoles has been reported as potent inhibitors of α-glucosidase. The procedure relies on the synthesis of 5-amino-1H-benzo[d]imidazole-2-thiol 5 via the multistep reaction through 2-nitroaniline 1, benzene-1,2-diamine 2, 1H-benzo[d]imidazole-2-thiol 3, and… read more here.
Keywords: arylideneamino benzo; ic50; ic50 ic50; imidazole thiols ... See more keywords