Transition-metal-free, atom-economical cascade synthesis of novel 2-sulfonated-benzo[f][1,7]naphthyridines and their cytotoxic activities
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DOI: 10.1016/j.tet.2018.02.023
Abstract: Abstract An efficient, transition-metal-free cascade synthetic method has been developed for new 2-aryl/heteroaryl sulfonated benzo[f][1,7]naphthyridines. It is tert-butyl hydroperoxide (TBHP) mediated highly regioselective sulfonylation‒cyclization‒aromatization process between N-(3-aryl/heteroarylprop-2-yn-1-yl)quinolin-3-amines and aryl/heteroaryl sulfonylhydrazides. This synthetic protocol offers one-step… read more here.
Keywords: benzo naphthyridines; transition metal; cytotoxic activities; metal free ... See more keywords
Rh(III)-Catalyzed Dual C-H Activation/Cascade Annulation of Benzimidates and CF3-Imidoyl Sulfoxonium Ylides for the Synthesis of Trifluoromethyl-Decorated Benzo[de][1,8]naphthyridines.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03666
Abstract: An efficient and straightforward approach for the synthesis of trifluoromethyl-decorated benzo[de][1,8]naphthyridines has been achieved via the Rh(III)-catalyzed dual C-H activation and cascade annulation of benzimidates and CF3-imidoyl sulfoxonium ylides. The novel transformation involves the formation… read more here.
Keywords: synthesis trifluoromethyl; decorated benzo; catalyzed dual; benzo naphthyridines ... See more keywords