Gestational exposure to nicotine and/or benzo[a]pyrene causes long-lasting neurobehavioral consequences.
Sign Up to like & getrecommendations! Published in 2019 at "Birth defects research"
DOI: 10.1002/bdr2.1568
Abstract: Tobacco smoke is a complex mixture that includes thousands of compounds. Previously, we have found that gestational exposure to the complex mixture of tobacco smoke extract caused long-term neurobehavioral impairments. In this study, we examined… read more here.
Keywords: gestational exposure; nicotine benzo; benzo pyrene; sex ... See more keywords
In Utero Exposure to Benzo[a]pyrene Induces Ovarian Mutations at Doses That Deplete Ovarian Follicles in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22261
Abstract: Polycyclic aromatic hydrocarbons like benzo[a]pyrene (BaP) are ubiquitous environmental contaminants formed during incomplete combustion of organic materials. Our prior work showed that transplacental exposure to BaP depletes ovarian follicles and increases prevalence of epithelial ovarian… read more here.
Keywords: ovarian mutations; exposure; benzo pyrene; ovarian follicles ... See more keywords
Bioaccumulation, Detoxification, and Biological Macromolecular Damage of Benzo[a]pyrene in Exposure in Tissues and Subcellular Fractions of Scallop Chlamys farreri
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology and Chemistry"
DOI: 10.1002/etc.5418
Abstract: Because of the persistence and high toxicity of benzo[a]pyrene (B[a]P), the bioaccumulation and detoxification mechanisms of B[a]P have been studied extensively at the tissue level; but the data at the subcellular level in bivalves have… read more here.
Keywords: bioaccumulation detoxification; subcellular fractions; benzo pyrene; damage ... See more keywords
Direct activation of aryl hydrocarbon receptor by benzo[a]pyrene elicits T‐helper 2‐driven proinflammatory responses in a mouse model of allergic dermatitis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3782
Abstract: The aryl hydrocarbon receptor (AhR) is a ligand‐dependent transcription factor that binds to various environmental chemicals and contributes to numerous toxicological effects. However, the direct effects of AhR on the development of allergic diseases are… read more here.
Keywords: hydrocarbon receptor; aryl hydrocarbon; benzo pyrene; activation ... See more keywords
Spectrochemical determination of effects on rat liver of binary exposure to benzo[a]pyrene and 2,2′,4,4′‐tetrabromodiphenyl ether
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4165
Abstract: Benzo[a]pyrene (B[a]P) and polybrominated diphenyl ethers (PBDEs) are persistent environmental contaminants. The effects in organisms of exposures to binary mixtures of such contaminants remain obscure. Attenuated total reflection Fourier‐transform infrared (ATR‐FTIR) spectroscopy is a label‐free,… read more here.
Keywords: tetrabromodiphenyl ether; binary exposure; exposure; benzo pyrene ... See more keywords
Detoxification of benzo[a]pyrene primarily depends on cytochrome P450, while bioactivation involves additional oxidoreductases including 5‐lipoxygenase, cyclooxygenase, and aldo‐keto reductase in the liver
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.21902
Abstract: Cytochrome P450s are involved in detoxification and activation of benzo[a]pyrene (BaP) with unclear balance and unknown contribution of other oxidoreductases. Here, we investigated the BaP and BaP‐induced mutagenicity in hepatic and extra‐hepatic tissues using hepatic… read more here.
Keywords: reductase; gpt mice; detoxification; benzo pyrene ... See more keywords
Protective effect of vanillic acid against benzo(a)pyrene induced lung cancer in Swiss albino mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22382
Abstract: Vanillic acid (VA) is found in high concentrations in various plants and used as traditional medicine for various diseases. The aim of the existing study is to illustrate the protective effects of VA against benzo(a)pyrene… read more here.
Keywords: vanillic acid; pyrene induced; benzo pyrene; induced lung ... See more keywords
Baicalein inhibits cell proliferation and enhances apoptosis in human A549 cells and benzo(a)pyrene‐induced pulmonary carcinogenesis in mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23053
Abstract: Our current study is done to explore the possible mechanisms to elaborate on the growth inhibitory effect of baicalein (BE) in human lung carcinoma. Initially, BE (25 and 50 µM) treatment for 24 h, suppressed the viability… read more here.
Keywords: cell; apoptosis; benzo pyrene; proliferation ... See more keywords
Protective role of AKBA against benzo(a)pyrene‐induced lung carcinogenesis by modulating biotransformation enzymes and oxidative stress
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23072
Abstract: The present study was designed to explore the chemopreventive potential of 3‐acetyl‐11‐keto‐β‐boswellic acid (AKBA) during the initiation and promotion stage of lung carcinogenesis induced by benzo(a)pyrene (BaP) in female Sprague Dawley rats. BaP was administered… read more here.
Keywords: lung carcinogenesis; bap; oxidative stress; benzo pyrene ... See more keywords
Ameliorative effect of dandelion (Taraxacum officinale) peptides on benzo(a)pyrene‐induced oxidative stress and inflammation in human umbilical vein endothelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Peptide Science"
DOI: 10.1002/psc.3447
Abstract: Dandelion (Taraxacum officinale) is widely consumed as a health food and a traditional medicine. However, the protective effect of dandelion bio‐active peptides (DPs) against polycyclic aromatic hydrocarbon‐induced blood vessel inflammation and oxidative damage is not… read more here.
Keywords: bap induced; benzo pyrene; dandelion taraxacum; effect dandelion ... See more keywords
Methanolic bark extract of Acacia catechu ameliorates benzo(a)pyrene induced lung toxicity by abrogation of oxidative stress, inflammation, and apoptosis in mice
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DOI: 10.1002/tox.22382
Abstract: Benzo(a)pyrene [B(a)P] is a well‐known carcinogen present in the environment. In this study, we evaluated the protective potential of methanolic bark extract of Acacia catechu Willd. (MEBA) against the lung toxicity induced by B(a)P in… read more here.
Keywords: bark extract; toxicity; benzo pyrene; mice ... See more keywords