Design, synthesis, anticonvulsant evaluation and docking study of 2-[(6-substituted benzo[d]thiazol-2-ylcarbamoyl)methyl]-1-(4-substituted phenyl)isothioureas.
Sign Up to like & getrecommendations! Published in 2017 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2017.02.009
Abstract: In this paper, we report the synthesis of 2-[(6-substituted benzo[d]thiazol-2-ylcarbamoyl)methyl]-1-(4-substituted phenyl)isothiourea derivatives (4a-y) carrying active pharmacophores essential for anticonvulsant activity. The anticonvulsant activity was evaluated in vivo by maximal electroshock (MES) test and subcutaneous pentylenetetrazole… read more here.
Keywords: thiazol ylcarbamoyl; methyl substituted; benzo thiazol; substituted phenyl ... See more keywords
Investigation of excited state proton transfer mechanism for 2-(benzo[d]thiazol-2-yl)naphthalene-1,3-diol in different solvents
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Physics"
DOI: 10.1016/j.chemphys.2020.110914
Abstract: Abstract This work systematically investigates solvent effects on hydrogen bond strength and excited-state intramolecular proton transfer (ESIPT) behaviour of 2-(benzo[d]thiazol-2-yl)naphthalene-1,3-diol (DHT) chromophore. The calculated electronic spectra accord with experimental observation. Our work confirms hydrogen bond… read more here.
Keywords: state; excited state; hydrogen bond; benzo thiazol ... See more keywords
Computational modelling of some anti-friction lubricant additives
Sign Up to like & getrecommendations! Published in 2020 at "South African Journal of Chemical Engineering"
DOI: 10.1016/j.sajce.2020.01.003
Abstract: Abstract Computational QSPR and MD simulation methods were used to design and assess new anti-friction lubricant additives. Four new additives were designed and butyl2-(benzo[d]thiazol-2-ylthio)-2-hydroxy acetate anti-friction additive was found to be excellently better than other… read more here.
Keywords: anti friction; friction; benzo thiazol; friction lubricant ... See more keywords
3-(Benzo[d]thiazol-2-yl)-4-aminoquinoline derivatives as novel scaffold topoisomerase I inhibitor via DNA intercalation: design, synthesis, and antitumor activities
Sign Up to like & getrecommendations! Published in 2020 at "New Journal of Chemistry"
DOI: 10.1039/c9nj05846j
Abstract: Twenty-seven 3-(benzo[d]thiazol-2-yl)-4-aminoquinoline derivatives have been designed and synthesized as topoisomerase I inhibitors. The in vitro anti-proliferation evaluation against four human cancer cell lines (MGC-803, HepG-2, T24, and NCI-H460) and one normal cell line (HL-7702) indicated… read more here.
Keywords: thiazol aminoquinoline; mgc 803; dna; benzo thiazol ... See more keywords
1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2018.1445736
Abstract: Abstract Several neurodegenerative disorders including Alzheimer’s disease (AD) have been connected with deregulation of casein kinase 1 (CK1) activity. Inhibition of CK1 therefore presents a potential therapeutic strategy against such pathologies. Recently, novel class of… read more here.
Keywords: treatment; neurodegenerative disorders; thiazol phenylureas; benzo thiazol ... See more keywords
Crystal structure of N-[3-(benzo[d]thiazol-2-yl)-6-bromo-2H-chromen-2-ylidene]-4-methylbenzenamine
Sign Up to like & getrecommendations! Published in 2023 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s2056989023002979
Abstract: In the crystal structure of the title compound, the C=N—C angle is wide [125.28 (8)°]. The benzothiazole and chromene ring systems are almost coplanar and lie parallel to (1 0); the toluene ring system is rotated… read more here.
Keywords: thiazol bromo; structure; benzo thiazol; bromo chromen ... See more keywords
Crystal structure of 3-(benzo[d]thiazol-2-yl)-6-methyl-2H-chromen-2-one
Sign Up to like & getrecommendations! Published in 2023 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s205698902300347x
Abstract: The title molecule is almost planar, with an intramolecular S⋯O=C contact. The packing is a layer structure with dimeric units connected by a C—H⋯O=C hydrogen bond. read more here.
Keywords: structure; benzo thiazol; methyl chromen; thiazol methyl ... See more keywords
Design, Synthesis, Molecular Docking, and Preliminary pharmacological screening of some new benzo[d]thiazol-2-ylamino containing chromen-2-one derivatives with atypical antipsychotic profile.
Sign Up to like & getrecommendations! Published in 2023 at "Current computer-aided drug design"
DOI: 10.2174/1573409919666230202105207
Abstract: INTRODUCTION Mental disorders are very serious complicated disorders. Schizophrenia is one of the most baffling mental disorders. The new series 7-(2-(benzo[d]thiazol-2-ylamino)ethoxy)-4-methyl-2H-chromen-2- 1(4a-4k) was synthesized in search of newer compounds for Schizophrenia. METHODS Synthesis is done… read more here.
Keywords: molecular docking; chromen one; thiazol ylamino; benzo thiazol ... See more keywords
Synthesis, antioxidant activity, and density functional theory study of some novel 4-[(benzo[d]thiazol-2-ylimino)methyl]phenol derivatives: a comparative approach for the explanation of their radical scavenging activities
Sign Up to like & getrecommendations! Published in 2021 at "Research in Pharmaceutical Sciences"
DOI: 10.4103/1735-5362.305187
Abstract: Background and purpose: Radicals produced by Fenton and Haber-Weiss reactions play detrimental roles in our body. Some oxidized proteins as toxic configurations are identified in amyloid-β deposits. These deposits mostly occur in conditions, such as… read more here.
Keywords: antioxidant activity; methyl phenol; benzo thiazol; thiazol ylimino ... See more keywords