Anti‐Quenching NIR‐II J‐Aggregates of Benzo[c]thiophene Fluorophore for Highly Efficient Bioimaging and Phototheranostics
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202211632
Abstract: Molecular fluorophores with the second near‐infrared (NIR‐II) emission hold great potential for deep‐tissue bioimaging owing to their excellent biocompatibility and high resolution. Recently, J‐aggregates are used to construct long‐wavelength NIR‐II emitters as their optical bands… read more here.
Keywords: benzo thiophene; bioimaging phototheranostics; nir aggregates; highly efficient ... See more keywords
Green emission band induced by crystal defects in halogenated (-Br, -Cl, -F) chiral imines with a benzo[b]thiophene-based moiety
Sign Up to like & getrecommendations! Published in 2019 at "Optical Materials"
DOI: 10.1016/j.optmat.2019.06.007
Abstract: Abstract Four different chiral imines were analyzed in solid state, by changing systematically the halogen atom –X (-F, -Cl and -Br) in the para-position of the benzene ring in the chiral moiety of benzo[b]thiophene-based imine… read more here.
Keywords: emission; thiophene based; chiral imines; benzo thiophene ... See more keywords
Sodium halides as the source of electrophilic halogens in green synthesis of 3-halo- and 3,n-dihalobenzo[b]thiophenes.
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.04.080
Abstract: A convenient methodology for the synthesis of mono- and di-halogenated benzo[b]thiophenes is described herein, which utilizes copper(II) sulfate pentahydrate and various sodium halides in the presence of substituted 2-alkynylthioanisoles. The proposed method is facile, uses… read more here.
Keywords: methodology; halides source; sodium halides; benzo thiophene ... See more keywords
2,3-Difunctionalized Benzo[b]thiophene Scaffolds Possessing Potent Antiangiogenic Properties.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00892
Abstract: A new class of 2-anilino-3-cyanobenzo[b]thiophenes (2,3-ACBTs) was studied for its antiangiogenic activity for the first time. One of the 2,3-ACBTs inhibited tubulogenesis in a dose-dependent manner without any toxicity. The 2,3-ACBTs significantly reduced neovascularization in… read more here.
Keywords: difunctionalized benzo; possessing potent; thiophene scaffolds; scaffolds possessing ... See more keywords
Discovery of dioxo-benzo[b]thiophene derivatives as potent YAP-TEAD interaction inhibitors for treating breast cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.2139/ssrn.4232369
Abstract: Disruption of protein-protein interaction between transcriptional enhancer factor (TEA)-domain (TEAD; a transcription factor) and its co-activator Yes-associated protein (YAP)/ transcriptional co-activator with PDZ-binding motif (TAZ) is a potential therapeutic strategy against various types of solid… read more here.
Keywords: interaction inhibitors; breast cancer; benzo thiophene; dioxo benzo ... See more keywords