Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy.
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DOI: 10.1021/acs.jmedchem.1c01219
Abstract: Increasing evidence shows that the CXC chemokine receptor 2 (CXCR2) signaling pathway is essentially implicated in the recruitment of myeloid-derived suppressor cells (MDSCs) to the tumor microenvironment and leads to MDSC-mediated immune suppression. Therefore, CXCR2… read more here.
Keywords: potent cxcr2; benzocyclic sulfone; sulfone derivatives; cancer immunotherapy ... See more keywords