Discovery of Potent Benzocycloalkane Derived Diapophytoene Desaturase Inhibitors with an Enhanced Safety Profile for the Treatment of MRSA, VISA, and LRSA Infections.
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DOI: 10.1021/acsinfecdis.7b00259
Abstract: Blocking the biosynthesis process of staphyloxanthin has emerged as a promising antivirulence strategy. Our previous research revealed that diapophytoene desaturase was an attractive and druggable target against infections caused by pigmented Staphylococcus aureus. Benzocycloalkane-derived compounds… read more here.
Keywords: staphylococcus aureus; desaturase inhibitors; desaturase; benzocycloalkane derived ... See more keywords