Mechanistic perspectives on piperidine-catalyzed synthesis of 1,5-benzodiazepin-2-ones
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DOI: 10.1016/j.mcat.2020.110774
Abstract: Abstract This work introduced new members to the pharmaceutical family of 1,5-benzodiazepin-2-ones, 2a–e. These compounds were synthesized in moderate yields via the reaction of 1,2-bifunctional substrates (α-cyanocinnamates) with o-phenylenediamine in xylene. The conduction of the… read more here.
Keywords: mechanistic perspectives; catalyzed synthesis; benzodiazepin ones; perspectives piperidine ... See more keywords
Rapid Access to Hindered α-Amino Acid Derivatives and Benzodiazepin-3-ones from Aza-Oxyallyl Cations.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c00023
Abstract: Catalyst-free and mild synthetic methods for the construction of hindered α-amino acid derivatives are presented herein. A wide range of hindered amino acid amides can be readily obtained from the reaction of α-halohydroxamates with a… read more here.
Keywords: amino acid; oxyallyl cations; benzodiazepin ones; aza oxyallyl ... See more keywords