Discovery of novel benzofuran scaffold as 4-hydroxyphenylpyruvate dioxygenase inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Pest management science"
DOI: 10.1002/ps.6159
Abstract: BACKGROUND 4-Hydroxyphenylpyruvate dioxygenase (HPPD) plays an important role in addressing the issue of plant protection research. This study sheds new light on the differences in molecular scaffold from commercialized HPPD inhibitors. RESULTS The compounds A1-A18… read more here.
Keywords: hppd inhibitors; hydroxyphenylpyruvate; hydroxyphenylpyruvate dioxygenase; benzofuran ... See more keywords
A new benzofuran derivative glycoside and a new coumarin glycoside from roots of Heracleum dissectum Ledeb
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-2073-9
Abstract: Heracleum dissectum Ledeb. is an ethnic herb used by Oroqen people in Northeast China. The roots of this plant are usually used for treatment of several diseases. However, chemical constituents and pharmacological study were rarely… read more here.
Keywords: dissectum ledeb; benzofuran derivative; heracleum dissectum; dissectum ... See more keywords
Insights into an alternative benzofuran binding mode and novel scaffolds of polyketide synthase 13 inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-019-4010-y
Abstract: AbstractSmall molecules targeting biosynthesis of mycolic acids in the tuberculosis causing bacterium carry high potential for anti-tuberculosis drug discovery. Hitherto, benzofuran containing molecules were identified to target the thioesterase domain of polyketide synthase 13 (Pks13),… read more here.
Keywords: methodology; screening; polyketide synthase; binding mode ... See more keywords
New route to synthesis of unexpected 1,5-bis(1-benzofuran-2-yl) pentane-1,5-dione derivatives: Their structure determination with spectroscopic and X-ray methods
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2016.10.063
Abstract: Abstract The new 1,5-bis(1-benzofuran-2-yl)-1,5-dione derivatives were obtained by the reaction of 2-acetyl benzofuran derivatives (1a–b) and suitable aromatic aldehyde derivatives (2-pyridinecarboxaldehyde, 2-fluoro and 3-fluorobenzaldehyde) in the presence of sodium hydroxide as the base. Importantly, a… read more here.
Keywords: bis benzofuran; ray; dione derivatives; benzofuran ... See more keywords
In vitro and in silico xanthine oxidase inhibitory potential of Benzofuran isolated from Viburnum grandiflorum Wall. Ex DC
Sign Up to like & getrecommendations! Published in 2021 at "South African Journal of Botany"
DOI: 10.1016/j.sajb.2021.01.010
Abstract: Abstract The study aimed to validate the folkloric medicinal uses of Viburnum grandiflorum. The column chromatography led to the isolation of a compound from the chloroform soluble fraction of V. grandiflorum which was characterized as… read more here.
Keywords: benzofuran; viburnum grandiflorum; xanthine oxidase; allopurinol ... See more keywords
Emission pathway switching by solvent polarity: Facile synthesis of benzofuran-bipyridine derivatives and turn-on fluorescence probe for zinc ions
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2016.12.039
Abstract: Bipyridine attached benzofuran derivatives were prepared by the cyclization of alkyne ortho-substituted phenols. Electronically different substituents, N,N-dibutylamino vs tert-butyl group, were attached on benzofuran rings. Depending on the polarity and pH of solvent environment, N,N-dialkylamino… read more here.
Keywords: emission pathway; bipyridine; polarity; zinc ions ... See more keywords
Structure Elucidation of Aroma-Active Bicyclic Benzofuran Derivatives Formed by Cystostereum murrayi.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.3c01807
Abstract: Among the monoterpenoid aroma compounds formed by the basidiomycete Cystostereum murrayi are highly potent bicyclic benzofuran derivatives. In addition to the dill ethers previously described in a few fungi, two stereoisomers of the rare 3,6-dimethyl-3a,4,5,6,7,7a-hexahydro-3H-1-benzofuran-2-one… read more here.
Keywords: benzofuran derivatives; bicyclic benzofuran; benzofuran; cystostereum murrayi ... See more keywords
Palladium-Mediated Functionalization of Benzofuran and Benzothiophene Cores
Sign Up to like & getrecommendations! Published in 2018 at "Organometallics"
DOI: 10.1021/acs.organomet.8b00682
Abstract: The palladation reactions of 2-heteroaromatic primary phenethylamines bearing a benzofuran and benzothiophene nuclei have been studied. We have assessed the reactivity of the corresponding dimeric six-membered palladacycles (arising from C–H metalation) toward neutral ligands and… read more here.
Keywords: benzofuran benzothiophene; mediated functionalization; functionalization benzofuran; palladium mediated ... See more keywords
Synthesis of Benzodioxane and Benzofuran Scaffolds Found in Neolignans via TMS Triflate Mediated Addition to 1,4-Benzodioxane Hemiacetals
Sign Up to like & getrecommendations! Published in 2017 at "Synthesis"
DOI: 10.1055/s-0036-1588939
Abstract: This research reports the successful asymmetric synthesis of both a 9-hydroxy-5′-methoxy-1,4-benzodioxane framework and a highly functionalised benzofuran scaffold. Both synthetically desirable structures are the result of a Lewis acid catalysed addition of an aryl nucleophile… read more here.
Keywords: addition; benzodioxane; synthesis benzodioxane; benzofuran scaffolds ... See more keywords
Discovery of New Heterocyclic/Benzofuran Hybrids as Potential Anti-Inflammatory Agents: Design, Synthesis, and Evaluation of the Inhibitory Activity of Their Related Inflammatory Factors Based on NF-κB and MAPK Signaling Pathways
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043575
Abstract: NF-κB and MAPK are classic inflammation signaling pathways which regulate inflammation signal transmission and induce the expression of many inflammatory factors. Based on the potent anti-inflammatory activity of benzofuran and its derivatives, several new heterocyclic/benzofuran… read more here.
Keywords: anti inflammatory; inflammatory; activity; benzofuran ... See more keywords
Exploring the Synergistic Anticancer Potential of Benzofuran–Oxadiazoles and Triazoles: Improved Ultrasound- and Microwave-Assisted Synthesis, Molecular Docking, Hemolytic, Thrombolytic and Anticancer Evaluation of Furan-Based Molecules
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27031023
Abstract: Ultrasound- and microwave-assisted green synthetic strategies were applied to furnish benzofuran–oxadiazole 5a–g and benzofuran–triazole 7a–h derivatives in good to excellent yields (60–96%), in comparison with conventional methods (36–80% yield). These synthesized derivatives were screened for… read more here.
Keywords: microwave assisted; potential; benzofuran; anticancer ... See more keywords