Resurrecting the Condemned: Identification of N-Benzoxaborole Benzofuran GSK8175 as a Clinical Candidate with Reduced Metabolic Liability.
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DOI: 10.1021/acs.jmedchem.9b00415
Abstract: Recently, in a program designed to improve the metabolic stability of the HCV inhibitor GSK5852, N-benzoxaborole benzofuran (GSK8175) emerged as a clinical candidate that not only retains the broad-spectrum activity against HCV subgenomic replicons but… read more here.
Keywords: benzoxaborole benzofuran; chemistry; clinical candidate; benzofuran gsk8175 ... See more keywords