N-Heterocyclic carbene catalyzed aza-benzoin reaction for access to α-aminoketone molecules containing benzothiazole fragments
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DOI: 10.1016/j.tet.2021.132311
Abstract: Abstract An N-Heterocyclic carbene (NHC) catalyzed aza-benzoin reaction of benzothiazole-2-carboxaldehydes and N-sulfonylimines is reported for the first time. The target benzothiazole-containing aminoketone products bearing different substituents and substitution patterns can be obtained in good to… read more here.
Keywords: aza benzoin; benzothiazole; catalyzed aza; benzoin reaction ... See more keywords
Chemoselective Intermolecular Cross-Benzoin Reaction of Aliphatic Aldehydes and Isatins via N-Heterocyclic Carbene Catalysis
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DOI: 10.1055/s-0037-1612250
Abstract: An N-heterocyclic carbene (NHC)-catalyzed chemoselective intermolecular cross-benzoin reaction of aliphatic aldehydes with isatins is developed, affording biologically important 3-substituted 3-hydroxyoxindoles (on gram scale) in moderate to good yields (46–90%). The employment of a morpholinone-derived pentafluorophenyl-substituted… read more here.
Keywords: cross benzoin; reaction; heterocyclic carbene; benzoin reaction ... See more keywords