Synthesis and Biological Activities of 11‐ and 12‐Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB and Tyrosyl‐DNA Phosphodiesterase 1 Inhibitors
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DOI: 10.1002/cmdc.202200593
Abstract: Herein, a series of 11‐ or 12‐substituted benzophenanthridinone derivatives was designed and synthesized for the discovery of dual topoisomerase IB (TOP1) and tyrosyl‐DNA phosphodiesterase 1 (TDP1) inhibitors. Enzyme‐based assays indicated that two compounds 12 and… read more here.
Keywords: topoisomerase; dna phosphodiesterase; benzophenanthridinone derivatives; substituted benzophenanthridinone ... See more keywords