Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization.
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DOI: 10.1021/acs.jmedchem.9b00551
Abstract: A promising design paradigm for small-molecule inhibitors of tubulin polymerization that bind to the colchicine site draws structural inspiration from the natural products colchicine and combretastatin A-4 (CA4). Our previous studies with benzocycloalkenyl and heteroaromatic… read more here.
Keywords: benzosuberene analogues; structure guided; tubulin polymerization; inhibitors tubulin ... See more keywords