Repositioning of Small Molecules through the Inverse Virtual Screening in silico Tool: Case of Benzothiazole-Based Inhibitors of Soluble Epoxide Hydrolase (sEH).
Sign Up to like & getrecommendations! Published in 2024 at "ChemPlusChem"
DOI: 10.1002/cplu.202400234
Abstract: Computational techniques accelerate drug discovery by identifying bioactive compounds for specific targets, optimizing molecules with moderate activity, or facilitating the repositioning of inactive items onto new targets. Among them, the Inverse Virtual Screening (IVS) approach… read more here.
Keywords: soluble epoxide; virtual screening; epoxide hydrolase; benzothiazole based ... See more keywords
Rational design of the benzothiazole-based fluorescent scaffold for tunable emission
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.03.029
Abstract: Abstract The 2-(2-hydroxyphenyl)-benzothiazole (HBT) fluorophore has attracted considerable attention due to its excited-state intramolecular proton transfer (ESIPT) based emission and its large Stokes shift. However, this fluorophore possesses several disadvantages including low quantum yield and… read more here.
Keywords: benzothiazole based; benzothiazole; rational design; emission ... See more keywords
Dinuclear Nickel Complexes Using Hexadentate Benzothiazole-Based Diamine-Bisphenolate Ligands: Highly Active Catalysts for Copolymerization of Carbon Dioxide with Epoxides.
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.2c01972
Abstract: We reported for the first time the utilization of hexadentate benzothiazole-based diamine-bisphenolate ligands to synthesize structurally well-characterized dinickel dicarboxylate complexes and studied their catalysis for copolymerization of carbon dioxide with epoxides. Dinickel carboxylate complexes having… read more here.
Keywords: based diamine; diamine bisphenolate; hexadentate benzothiazole; bisphenolate ligands ... See more keywords
Thiazole- and Benzothiazole-Based Organoselenium Compounds as Dual-Action Agents: Tyrosinase Inhibitors and Functional Mimics of Glutathione Peroxidase.
Sign Up to like & getrecommendations! Published in 2025 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.5c02356
Abstract: Hydrogen peroxide regulates tyrosinase activity, a key enzyme in melanogenesis, underscoring the importance of redox balance in melanin biosynthesis. A new class of thiazole- and benzothiazole-based selones and their sulfur analogues was synthesized and structurally… read more here.
Keywords: thiazole benzothiazole; benzothiazole based; glutathione peroxidase; tyrosinase inhibitors ... See more keywords
Synthetic strategies towards benzothiazole-based compounds of therapeutic potency: experimental, investigational and approved drugs
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DOI: 10.1039/d5ra03993b
Abstract: Benzothiazoles play significant roles in modern therapeutical chemistry owing to their significant effects and their integration into various pharmaceutical agents for treating critical diseases. Several approved, investigational, and experimental benzothiazole-based drugs have been accomplished. Novel… read more here.
Keywords: towards benzothiazole; based compounds; benzothiazole based; compounds therapeutic ... See more keywords
Benzothiazole-based Arylamines as Hole Transporting Materials for Perovskite Solar Cells
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DOI: 10.1039/d5tc01318f
Abstract: The performance of perovskite solar cells (PSCs) is partially dependent on the properties of the hole transporting material (HTM) used. Here, we present the synthesis and study of novel benzothiazole-based... read more here.
Keywords: hole transporting; solar cells; benzothiazole based; arylamines hole ... See more keywords
Benzothiazole-based Compounds in Antibacterial Drug Discovery.
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DOI: 10.2174/0929867324666171009103327
Abstract: Numerous compounds with a benzothiazole scaffold that have been described in the literature show promising activities against several Gram-positive and Gramnegative bacteria, and also against Mycobacterium tuberculosis. Benzothiazole-based antibacterial compounds bind to different biological targets… read more here.
Keywords: bacterial cells; benzothiazole; antibacterial drug; benzothiazole based ... See more keywords
New Benzothiazole-based Thiazolidinones as Potent Antimicrobial Agents. Design, synthesis and Biological Evaluation.
Sign Up to like & getrecommendations! Published in 2018 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026618666180206101814
Abstract: BACKGROUND Thiazole and benzothiazole derivatives, as well as thiazolidinones are very important scaffolds in medicinal chemistry. Literature has revealed that they possess a wide spectrum of biological activities including antimicrobial activity. OBJECTIVE The goal of… read more here.
Keywords: benzothiazole; chemistry; benzothiazole based; based thiazolidinones ... See more keywords