Design, Synthesis, and Evaluation of Bis‐Benzothiazole Derivatives as DNA Minor Groove Binding Agents
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.3041
Abstract: A series of novel bis-benzothiazole derivatives with head-to-head orientation were designed, synthesized, and evaluated for their anti-proliferative activities on U937, HL60, and HeLa cells. A significant part of the targets exhibited considerable in vitro anticancer… read more here.
Keywords: design synthesis; bis benzothiazole; minor groove; benzothiazole derivatives ... See more keywords
99mTc-radiolabeled imidazo[2,1-b]benzothiazole derivatives as potential radiotracers for glioblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Radioanalytical and Nuclear Chemistry"
DOI: 10.1007/s10967-019-06945-4
Abstract: This study presents [99mTc]BPTG-1 and [99mTc]BPTG-2 for glioblastoma imaging. In vitro cellular uptakes of these radiotracers were examined in SKOV-3, MCF-7, U87-MG, HT-29, and A549 cell lines. U87-MG cell line displayed the highest radiotracers uptakes.… read more here.
Keywords: 99mtc radiolabeled; radiolabeled imidazo; benzothiazole derivatives; potential radiotracers ... See more keywords
Synthesis of benzothiazole derivatives as a potent α-glucosidase inhibitor.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.12.021
Abstract: Diabetes is one of the pre-dominant metabolic disorders all over the world. It is the prime reason of mortality and morbidity due to hyperglycemia which is link with numerus obstacles. Delaying absorption and digestion of… read more here.
Keywords: benzothiazole; potent glucosidase; synthesis benzothiazole; derivatives potent ... See more keywords
Targeting Receptor-Interacting Protein Kinase 1 by Novel Benzothiazole Derivatives: Treatment of Acute Lung Injury through the Necroptosis Pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00197
Abstract: Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) are serious and devastating pulmonary manifestations of acute systemic inflammation with high morbidity and mortality worldwide. Currently, there are no specific effective treatments for ALI/ARDS. RIPK1, which contributes… read more here.
Keywords: acute lung; acute; lung injury; benzothiazole derivatives ... See more keywords
Insertion Reaction of 2-Halo-N-allylanilines with K2S Involving Trisulfur Radical Anion: Synthesis of Benzothiazole Derivatives under Transition-Metal-Free Conditions
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DOI: 10.1055/s-0040-1706104
Abstract: A synthesis of benzothiazole derivatives through the reaction of 2-halo-N-allylanilines with K2S in DMF is developed. The trisulfur radical anion S3·–, which is generated in situ from K2S in DMF, initiates the reaction without transition-metal… read more here.
Keywords: benzothiazole; synthesis benzothiazole; reaction halo; benzothiazole derivatives ... See more keywords
Novel Benzothiazole Derivatives Synthesis and its Analysis as Diuretic Agents
Sign Up to like & getrecommendations! Published in 2023 at "Evidence-Based Complementary and Alternative Medicine"
DOI: 10.1155/2023/5460563
Abstract: Benzothiazoles, an anticonvulsant, antiviral, antihypertensive, and cancer-fighting medication of the heterocyclic scaffold family, also acts as antibacterial and antiviral agents. There is much interest in this chemical’s production because of the strong and vital biological… read more here.
Keywords: derivatives synthesis; analysis diuretic; novel benzothiazole; synthesis analysis ... See more keywords
Benzothiazole Derivatives as Multifunctional Antioxidant Agents for Skin Damage: Structure–Activity Relationship of a Scaffold Bearing a Five-Membered Ring System
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11020407
Abstract: Skin diseases often give multifactorial damages; therefore, the development of multifunctional compounds represents a suitable approach especially against disorders that are induced by oxidative stress. Thus, taking into account the successful results we achieved on… read more here.
Keywords: multifunctional antioxidant; agents skin; derivatives multifunctional; benzothiazole derivatives ... See more keywords