Synthesis of Benzothiazolopyrimidine Diastereomers Through a Copper‐Catalyzed Azide–Alkyne Cycloaddition/Ring‐Cleavage/[4 + 2] Cycloaddition Sequence
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DOI: 10.1002/ejoc.202500714
Abstract: Copper‐catalyzed reactions of 2‐benzothiazolimines, terminal ynones, and sulfonyl azides afforded benzothiazolopyrimidine diastereomers. The transformation involved a tandem CuAAC/ring‐cleavage/[4 + 2] cycloaddition procedure with one‐pot synthesis under mild conditions. The benzothiazolopyrimidine diastereomers could be isolated, and their structure… read more here.
Keywords: ring cleavage; copper catalyzed; benzothiazolopyrimidine diastereomers; cycloaddition ... See more keywords