Tagged Benzoxazin‐4‐Ones as Novel Activity‐Based Probes for Serine Proteases
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DOI: 10.1002/cbic.202000848
Abstract: Activity‐based probes (ABPs) are valuable chemical tools for profiling enzymes. They have been particularly useful in the study of proteases. ABPs rely on electrophilic scaffolds that covalently modify the target enzymes. Ideally, they can be… read more here.
Keywords: serine proteases; tagged benzoxazin; benzoxazin ones; activity based ... See more keywords
Synthesis of 4H-1,3-benzoxazin-4-ones from 2,2-diazidobenzofuran-3(2H)-ones
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DOI: 10.1016/j.tet.2018.12.001
Abstract: Abstract Benzoxazine derivatives are useful building blocks and display various biological activities. We serendipitously discovered and subsequently developed a new one pot method for the synthesis of 2-(dimethyl amino)/2-morpholino/2- (piperidin-1-yl)-4H-benzo[e][1,3]oxazin-4-ones from corresponding substituted 2,2-diazidobenzofuran 3(2H)… read more here.
Keywords: diazidobenzofuran ones; synthesis; synthesis benzoxazin; ones diazidobenzofuran ... See more keywords
Direct oxidative cascade cyclisation of 2-aminobenzoic acid and arylaldehydes to aryl 4H-3,1-benzoxazin-4-ones with oxone
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DOI: 10.1016/j.tetlet.2016.12.072
Abstract: Abstract This paper presents a methodology of oxidative cascade cyclisation of 2-aminobenzoic acids and arylaldehyde using I 2 as a catalyst and an environmentally benign oxidant oxone. This method displays facile access to a diverse… read more here.
Keywords: methodology; cyclisation aminobenzoic; aryl benzoxazin; benzoxazin ones ... See more keywords
Copper-catalyzed direct coupling of benzoxazin-2-ones with indoles for the synthesis of diverse 3-indolylbenzoxazin-2-ones: access to natural cephalandole A
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DOI: 10.1039/c7ra10634c
Abstract: A novel and facile copper-catalyzed direct coupling for the synthesis of diverse and functionalized 3-indolyl benzoxazin-2-ones from benzoxazin-2-ones and indoles has been developed. This new methodology offers an easy and rapid approach to a variety… read more here.
Keywords: benzoxazin ones; ones indoles; direct coupling; synthesis diverse ... See more keywords
Copper-catalyzed oxidative phosphonation of 3,4-dihydro-1,4-benzoxazin-2-ones
Sign Up to like & getrecommendations! Published in 2018 at "Organic chemistry frontiers"
DOI: 10.1039/c8qo01049h
Abstract: A straight-forward and atom-economical Cu(II)/PBQ-catalyzed oxidative phosphonation of 3,4-dihydro-1,4-benzoxazin-2-ones has been developed through an OEO involving oxidative Pudovik reaction. The experiments are performed under mild reaction conditions to construct new Csp3–P bonds and provide a… read more here.
Keywords: benzoxazin ones; oxidative phosphonation; dihydro benzoxazin; phosphonation dihydro ... See more keywords
Base-Promoted Chemodivergent Formation of 1,4-Benzoxazepin-5(4H)-ones and 1,3-Benzoxazin-4(4H)-ones Switched by Solvents
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DOI: 10.3390/molecules24203773
Abstract: The KOH-promoted chemodivergent benzannulation of ortho-fluorobenzamides with 2-propyn-1-ol can afford either 1,4-benzoxazepin-5(4H)-ones or 1,3-benzoxazin-4(4H)-ones in good yields with high selectivity, depending greatly upon the use of solvents. In the case of using DMSO, the intermolecular… read more here.
Keywords: promoted chemodivergent; benzoxazin ones; ones benzoxazin; membered benzo ... See more keywords