Negative allosteric modulators of NMDA receptors with GluN2B subunit: Alanine‐derived benzoxazolone bioisosteres of 2‐methyl‐3‐benzazepine‐1,7‐diols
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DOI: 10.1002/ardp.202200177
Abstract: Inspired by besonprodil, the phenol of potent negative allosteric modulators of GluN2B‐N‐methyl‐d‐aspartate (NMDA) receptors was replaced by a benzoxazolone system. To increase the similarity to the lead compounds, an additional methyl moiety was installed in… read more here.
Keywords: nmda receptors; allosteric modulators; moiety; benzoxazolone ... See more keywords
Multifunctional agents based on benzoxazolone as promising therapeutic drugs for diabetic nephropathy.
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DOI: 10.1016/j.ejmech.2021.113269
Abstract: Diabetic nephropathy (DN) is resulted from activations of polyol pathway and oxidative stress by abnormal metabolism of glucose, and no specific medication is available. We designed a novel class of benzoxazolone derivatives, and a number… read more here.
Keywords: polyol pathway; based benzoxazolone; benzoxazolone; diabetic nephropathy ... See more keywords
Studies on new 2(3H)-benzoxazolone derivatives: synthesis, characterization and cytotoxic effects
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DOI: 10.1016/j.jbiotec.2019.05.285
Abstract: 2(3H)-Benzoxazolone derivatives have been reported to show diverse biological activities depending on the position and type of the substituent. Recent studies show that these types of molecules could also show promising anticancer activities. A series… read more here.
Keywords: studies new; new benzoxazolone; benzoxazolone derivatives; derivatives synthesis ... See more keywords