Synthesis and molecular modeling studies of 1-benzyl-2-indolinones as selective AChE inhibitors.
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DOI: 10.4155/fmc-2022-0139
Abstract: Background: Possible bioisosteres can be developed by replacing the 1-indanone ring (one of three pharmacophore groups) of donepezil with an indoline ring. As H2S donors, thioamide, thiocarbamate and thiourea groups are also critically important. Materials… read more here.
Keywords: synthesis molecular; molecular modeling; modeling studies; benzyl indolinones ... See more keywords