Direct Reductive Arylation of Imines with Electron-Deficient (Hetero) Arenes via Electrosynthesis to Access Benzylic Amines.
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DOI: 10.1021/acs.orglett.2c02900
Abstract: In this paper, a direct access to benzylic amines from imines and electron-deficient (hetero) arenes via electrochemical radical-radical cross-coupling is described. The reaction has the characteristics of the wide range of substrates, excellent functional group… read more here.
Keywords: electron deficient; imines electron; benzylic amines; deficient hetero ... See more keywords
Copper-Catalyzed Stereospecific C–S Coupling Reaction of Enantioenriched Tertiary Benzylic Amines via in Situ Activation with Methyl Triflate
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DOI: 10.1021/acscatal.8b03032
Abstract: A one-pot protocol for the synthesis of highly enantiopure benzylic thioethers, thioacetates, and sulfones (94–99% ee) via a ligand-free, copper-catalyzed stereospecific C–S coupling reaction of thiols and enantioenriched tertiary benzylic amines via in situ activation… read more here.
Keywords: benzylic amines; tertiary benzylic; coupling reaction; enantioenriched tertiary ... See more keywords
Transient directing group enabled Pd-catalyzed C–H oxygenation of benzaldehydes and benzylic amines
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DOI: 10.1039/d2ra00241h
Abstract: We report a general protocol for ortho-C–H fluoroalkoxylation of benzaldehydes and benzylic amines utilizing an inexpensive amino amide as a transient directing group. In the presence of an electrophilic fluorinating bystanding oxidant and fluorinated alcohols,… read more here.
Keywords: transient directing; benzaldehydes benzylic; benzylic amines; group enabled ... See more keywords