Synthesis and in vitro study of antiproliferative benzyloxy dihydropyrimidinones
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DOI: 10.1002/ardp.202000466
Abstract: In this study, we report on antiproliferative benzyloxy dihydropyrimidinones (DHPMs) produced by the Biginelli reaction of benzyloxy benzaldehyde, urea, and diverse 1,3‐diones. The reaction was catalyzed by lanthanum triflate and completed within 1–1.5 h, with 74–97%… read more here.
Keywords: benzyloxy; benzyloxy dihydropyrimidinones; antiproliferative benzyloxy; study ... See more keywords
Design and synthesis of novel benzyloxy-tethered-chromone-carboxamide derivatives as potent and selective human monoamine oxidase-b inhibitors
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DOI: 10.1007/s11696-020-01332-w
Abstract: A series of new bifunctional 7-benzyloxy-2, 3-dimethyl-4-oxo-4H-chromene-8-carboxamides 5a - 5 l were synthesized from 7-hydroxy 2,3 dimethyl chromone via key intermediate 7-benzyloxy 2,3 dimethyl-8-carboxylic acid using Jones oxidation and HBTU/HOBt (Hexafluorophosphate Benzotriazole Tetramethyl Uronium/Hydroxybenzotriazole) as selective… read more here.
Keywords: benzyloxy; human monoamine; chromone; monoamine oxidase ... See more keywords
Stereoselective synthesis of the four 16-hydroxymethyl-3-methoxy- and 16-hydroxymethyl-3-benzyloxy-13α-estra-1,3,5(10)-trien-17-ol isomers and their antiproliferative activities
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DOI: 10.1016/j.steroids.2018.02.008
Abstract: Graphical abstract Figure. No caption available. HighlightsStereoselective synthesis of diastereomeric diols.Straightforward synthetic route from trans‐ to cis‐diols.Substantial antiproliferative action against HeLa. &NA; The reduction of 16‐hydroxymethylene‐3‐methoxy‐13&agr;‐estra‐1,3,5(10)‐trien‐17‐one (14) and 16‐hydroxymethylene‐3‐benzyloxy‐13&agr;‐estra‐1,3,5(10)‐trien‐17‐one (16) yielded a mixture of two… read more here.
Keywords: benzyloxy; hydroxymethyl; estra trien; antiproliferative activities ... See more keywords
(E)-2-{[(2-Aminophenyl)imino]methyl}-5-(benzyloxy)phenol and (Z)-3-benzyloxy-6-{[(5-chloro-2-hydroxyphenyl)amino]methylidene}cyclohexa-2,4-dien-1-one
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DOI: 10.1107/s2056989018005662
Abstract: The synthesis and structures of (E)-2-{[(2-aminophenyl)imino]methyl}-5-(benzyloxy)phenol (I) and (Z)-3-benzyloxy-6-{[(5-chloro-2-hydroxyphenyl)amino]methylidene}cyclohexa-2,4-dien-1-one (II) are reported. The crystal structures of the molecules are stabilized by N—H⋯O, O—H⋯O and C—H⋯π contacts. DFT calculations on the structure of (II) support the… read more here.
Keywords: phenol benzyloxy; benzyloxy; methyl benzyloxy; benzyloxy phenol ... See more keywords