Discovery of Benzylpiperazine Derivatives as CNS-Penetrant and Selective Histone Deacetylase 6 Inhibitors.
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DOI: 10.1021/acsmedchemlett.2c00081
Abstract: Inhibition of histone deacetylase 6 (HDAC6) in the brain is a highly attractive therapeutic target for the treatment of neurodegenerative diseases. The low blood-brain barrier permeability of most known HDAC6 inhibitors, however, prevents their application… read more here.
Keywords: cns penetrant; hdac6 inhibitors; histone deacetylase; benzylpiperazine derivatives ... See more keywords