d-Tubocurarine and Berbamine: Alkaloids That Are Permeant Blockers of the Hair Cell's Mechano-Electrical Transducer Channel and Protect from Aminoglycoside Toxicity
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2017.00262
Abstract: Aminoglycoside antibiotics are widely used for the treatment of life-threatening bacterial infections, but cause permanent hearing loss in a substantial proportion of treated patients. The sensory hair cells of the inner ear are damaged following… read more here.
Keywords: hair cell; hair cells; hair; berbamine ... See more keywords
Berbamine Analogs Exhibit Differential Protective Effects From Aminoglycoside-Induced Hair Cell Death
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.00234
Abstract: Hearing loss is the third most common chronic health condition in the United States and largely results from damage to sensory hair cells. Major causes of hair cell damage include aging, noise exposure, and medications… read more here.
Keywords: protection; hair cells; hair; berbamine ... See more keywords
Berbamine inhibits RANKL- and M-CSF-mediated osteoclastogenesis and alleviates ovariectomy-induced bone loss
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1032866
Abstract: Osteoporosis is a common public health problem characterized by decreased bone mass, increased bone brittleness and damage to the bone microstructure. Excessive bone resorption by osteoclasts is the main target of the currently used drugs… read more here.
Keywords: ovariectomy induced; bone; osteoporosis; bone loss ... See more keywords
Berbamine Reduces Chloroquine-Induced Itch in Mice through Inhibition of MrgprX1
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DOI: 10.3390/ijms232214321
Abstract: Chloroquine (CQ) is an antimalaria drug that has been widely used for decades. However, CQ-induced pruritus remains one of the major obstacles in CQ treatment for uncomplicated malaria. Recent studies have revealed that MrgprX1 plays… read more here.
Keywords: induced pruritus; induced itch; mrgprx1; berbamine ... See more keywords