The synthesis and antistaphylococcal activity of 9, 13-disubstituted berberine derivatives.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.01.012
Abstract: A series of novel 9, 13-disubstituted berberine derivatives have been synthesized and evaluated for the antibacterial activities against Staphylococcus aureus, including Newman strain and multidrug-resistant strains (NRS-1, NRS-70, NRS-100, NRS-108, and NRS-271). Compound 20 shows… read more here.
Keywords: berberine derivatives; disubstituted berberine; synthesis antistaphylococcal; antistaphylococcal activity ... See more keywords
Structural exploration of common pharmacophore based berberine derivatives as novel histone deacetylase inhibitor targeting HDACs enzymes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2021.2024254
Abstract: Abstract Histone deacetylase (HDAC) inhibitors, are new class of cancer chemotherapeutics used in clinical development. It plays a pivotal role in restoring the acetylation balance and lysine residual deacetylation in histone and non-histone proteins. Notably,… read more here.
Keywords: structural exploration; pharmacophore based; histone; berberine derivatives ... See more keywords
A patent review of berberine and its derivatives with various pharmacological activities (2016-2020).
Sign Up to like & getrecommendations! Published in 2021 at "Expert opinion on therapeutic patents"
DOI: 10.1080/13543776.2021.1974001
Abstract: INTRODUCTION Berberine (BBR), as one of the outstanding representatives of isoquinoline alkaloids, has been used as an antibacterial drug for a long time in China since ancient times. Currently, a large number of studies have… read more here.
Keywords: patent review; pharmacological activities; berberine derivatives; 2016 2020 ... See more keywords
Probing the Efficiency of 13-Pyridylalkyl Berberine Derivatives to Human Telomeric G-Quadruplexes Binding: Spectroscopic, Solid State and In Silico Analysis
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DOI: 10.3390/ijms232214061
Abstract: The interaction between the series of berberine derivatives 1–5 (NAX071, NAX120, NAX075, NAX077 and NAX079) and human telomeric G-quadruplexes (G4), which are able to inhibit the Telomerase enzyme’s activity in malignant cells, was investigated. The… read more here.
Keywords: telomeric quadruplexes; solid state; analysis; human telomeric ... See more keywords
Synthesis of 10-O-aryl-substituted berberine derivatives by Chan–Evans–Lam coupling and investigation of their DNA-binding properties
Sign Up to like & getrecommendations! Published in 2021 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.17.81
Abstract: Eleven novel 10-O-aryl-substituted berberrubine and berberine derivatives were synthesized by the Cu2+-catalyzed Chan–Evans–Lam coupling of berberrubine with arylboronic acids and subsequent 9-O-methylation. The reaction is likely introduced by the Cu2+-induced demethylation of berberrubine and subsequent… read more here.
Keywords: aryl substituted; lam coupling; dna; evans lam ... See more keywords