Differential effects of Wnt-β-catenin signaling in Purkinje cells and Bergmann glia in spinocerebellar ataxia type 1
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208513119
Abstract: Significance The mechanisms underlying the degeneration of specific cellular populations in various neurodegenerative disorders remain unknown. Here, we show that the polyQ expansion of ataxin-1 activates the Wnt-β-catenin signaling pathway in various cell types, including… read more here.
Keywords: bergmann glia; wnt catenin; purkinje cells; catenin signaling ... See more keywords
Propofol Exposure in Early Life Induced Developmental Impairments in the Mouse Cerebellum
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2017.00373
Abstract: Propofol is a widely used anesthetic in the clinic while several studies have demonstrated that propofol exposure may cause neurotoxicity in the developing brain. However, the effects of early propofol exposure on cerebellar development are… read more here.
Keywords: bergmann glia; propofol; exposure early; propofol exposure ... See more keywords