Abstract GMM-048: CTDNA RESPONSE TO THE PARP INHIBITOR RUCAPARIB PREDICTS PROGRESSION-FREE SURVIVAL AND BEST OVERALL RESPONSE ON THE ARIEL2 TRIAL
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DOI: 10.1158/1557-3265.ovcasymp18-gmm-048
Abstract: BACKGROUND: High grade serous ovarian carcinoma (HGSOC) is characterized by ubiquitous TP53 mutation and has the highest genomic complexity of all epithelial neoplasms. Sensitivity to PARP inhibitor therapy is strongly associated with homologous recombination deficiency… read more here.
Keywords: response; ctdna; overall response; rucaparib ... See more keywords
Laparoscopic twist technique has the best overall artifact profile when comparing three laparoscopic hepatic cup biopsy techniques for dogs.
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DOI: 10.2460/ajvr.22.08.0127
Abstract: OBJECTIVE To determine the difference in histologic artifacts and morphologic diagnosis among 3 laparoscopic cup biopsy forceps techniques and wedge hepatic samples. ANIMALS Cadavers of 20 client-owned dogs following euthanasia for unrelated reasons between January… read more here.
Keywords: best overall; biopsy techniques; cup biopsy; biopsy ... See more keywords
A Somatic Mutation Signature Predicts the Best Overall Response to Anti-programmed Cell Death Protein-1 Treatment in Epidermal Growth Factor Receptor/Anaplastic Lymphoma Kinase-Negative Non-squamous Non-small Cell Lung Cancer
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DOI: 10.3389/fmed.2022.808378
Abstract: Background We aimed to exploit a somatic mutation signature (SMS) to predict the best overall response to anti-programmed cell death protein-1 (PD-1) therapy in non-small cell lung cancer (NSCLC). Methods Tumor samples of 248 patients… read more here.
Keywords: cell; best overall; negative non; non squamous ... See more keywords