1,4‐Dihydropyridinebutyrolactone‐derived ring‐opened ester and amide analogs targeting BET bromodomains
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200288
Abstract: Based on a previously reported 1,4‐dihydropyridinebutyrolactone virtual screening hit, nine lactone ring‐opened ester and seven amide analogs were prepared. The analogs were designed to provide interactions with residues at the entrance of the ZA loop… read more here.
Keywords: bet; bet bromodomains; amide analogs; opened ester ... See more keywords
The loss‐bet paradox: Actuaries, accountants, and other numerate people rate numerically inferior gambles as superior
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Behavioral Decision Making"
DOI: 10.1002/bdm.2085
Abstract: Abstract Psychologists have convincingly demonstrated that preferences are not always stable and, instead, are often “constructed” based on information available in the judgment or decision context. In 4 studies with experts (accountants and actuaries in… read more here.
Keywords: bet; effect; paradox actuaries; bet paradox ... See more keywords
BET‐ting on Nrf2: How Nrf2 Signaling can Influence the Therapeutic Activities of BET Protein Inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "BioEssays"
DOI: 10.1002/bies.201800007
Abstract: BET proteins such as Brd3 and Brd4 are chromatin‐associated factors, which control gene expression programs that promote inflammation and cancer. The Nrf2 transcription factor is a master regulator of genes that protect the organism against… read more here.
Keywords: nrf2 bet; bet proteins; ting nrf2; bet ting ... See more keywords
Persistently active interferon-γ pathway and expansion of T-bet+ B cells in a subset of patients with childhood-onset systemic lupus erythematosus.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250319
Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease causing significant morbidity and mortality, despite important improvements in its management in the last decades. The objective of this work is to investigate the role of IFN-γ… read more here.
Keywords: lupus erythematosus; ifn; systemic lupus; bet ... See more keywords
A new BET inhibitor, 171, inhibits tumor growth through cell proliferation inhibition more than apoptosis induction
Sign Up to like & getrecommendations! Published in 2019 at "Investigational New Drugs"
DOI: 10.1007/s10637-019-00818-z
Abstract: The bromodomain and extra-terminal domain (BET) family of proteins, especially bromodomain-containing protein 4 (BRD4), has emerged as exciting anti-tumor targets due to their important roles in epigenetic regulation. Therefore, the discovery of BET inhibitors with… read more here.
Keywords: compound 171; apoptosis; bet; anti tumor ... See more keywords
Effects of dietary methionine and betaine on slaughter performance, biochemical and enzymatic parameters in goose liver and hepatic composition
Sign Up to like & getrecommendations! Published in 2017 at "Animal Feed Science and Technology"
DOI: 10.1016/j.anifeedsci.2017.04.003
Abstract: Abstract The effects of dietary methionine (Met) and betaine (Bet) on slaughter performance, serum biochemical parameters, and liver betaine-homocysteine methyltransferase (BHMT) were investigated in geese. Six Met-deficient diets were prepared according to a 2 × 3 factorial… read more here.
Keywords: supplementation; slaughter performance; bet; performance ... See more keywords
Optimization of orodispersible and conventional tablets using simplex lattice design: Relationship among excipients and banana extract.
Sign Up to like & getrecommendations! Published in 2018 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2018.03.087
Abstract: The objective of this study was focused on the optimization of the pharmaceutical excipients and banana extract in the preparation of orally disintegrating banana extract tablets (OD-BET) and conventional banana extract tablets (CO-BET) using a… read more here.
Keywords: banana extract; bet; using simplex; simplex lattice ... See more keywords
Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.07.034
Abstract: SUMMARY Following infection, inflammatory cues upregulate core transcriptional programs to establish pathogen-specific protection. In viral infections, T follicular helper (TFH) cells express the prototypical T helper 1 transcription factor T-bet. Several studies have demonstrated essential… read more here.
Keywords: role bet; infection; bet; follicular helper ... See more keywords
BET protein inhibition promotes non-myeloid cell mediated neuroprotection after rodent spinal cord contusion
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2022.114035
Abstract: Spinal cord injuries (SCI) often lead to multiple neurological deficits as a result from the initial trauma and also the secondary damage that follows. Despite abundant preclinical data proposing anti-inflammatory therapies to minimize secondary injury… read more here.
Keywords: bet; inhibition; bet protein; bet proteins ... See more keywords
A monocyte-keratinocyte-derived co-culture assay accurately identifies efficacies of BET inhibitors as therapeutic candidates for psoriasiform dermatitis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2020.08.005
Abstract: BACKGROUND Bromodomain and extra-terminal (BET) proteins perform key roles in epigenetic control of gene expression that is involved in inflammatory conditions, including psoriasiform dermatitis (PsD). Predicting which (of many potential available BET inhibitors) will be… read more here.
Keywords: psoriasiform dermatitis; bet; bet inhibitors; monocyte keratinocyte ... See more keywords
Procedural and 12 month in-hospital costs of primary infra-popliteal bypass surgery, infra-popliteal best endovascular treatment, and major lower limb amputation for Chronic Limb Threatening Ischaemia.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of vascular surgery"
DOI: 10.1016/j.jvs.2021.07.232
Abstract: BACKGROUND Chronic limb threatening ischaemia (CLTI) is a growing global problem due to the widespread use of tobacco and increasing prevalence of diabetes. Although the financial consequences are considerable, few studies have compared the relative… read more here.
Keywords: limb; bet; mlla; cost ... See more keywords