BET family protein degraders poised to join the senolytic arsenal
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-0202-2
Abstract: In a recent study published in Nature Communications, Wakita et al. identified BET family protein degrader (BETd) as a novel senolytic drug through high-throughput screening and biofunctional assays. BETd preferentially eliminated senescent cells by targeting… read more here.
Keywords: senescent cells; treatment; bet family; arv825 treatment ... See more keywords
A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15719-6
Abstract: Although cellular senescence acts primarily as a tumour suppression mechanism, the accumulation of senescent cells in vivo eventually exerts deleterious side effects through inflammatory/tumour-promoting factor secretion. Thus, the development of new drugs that cause the… read more here.
Keywords: senescent cells; family protein; provokes senolysis; protein degrader ... See more keywords
Bromodomain and BET family proteins as epigenetic targets in cancer therapy: their degradation, present drugs, and possible PROTACs
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DOI: 10.1039/d0ra07971e
Abstract: Alteration in the pattern of epigenetic marking leads to cancer, neurological disorders, inflammatory problems etc. These changes are due to aberration in histone modification enzymes that function as readers, writers and erasers. Bromodomains (BDs) and… read more here.
Keywords: epigenetic targets; bet family; bromodomain bet; cancer ... See more keywords
Abstract 1382: A novel BET family bromodomain inhibitor NHWD-870 represents a promising therapeutic agent for a broad spectrum of cancers
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DOI: 10.1158/1538-7445.am2017-1382
Abstract: Small molecule inhibitors of the bromodomain and extraterminal domain (BET) proteins have emerged as a promising option for cancer therapy. NHWD-870 is a potent and selective BET family bromodomain inhibitor and only binds bromodomains of… read more here.
Keywords: family bromodomain; bromodomain inhibitor; nhwd 870; cancer ... See more keywords
Relevance of BET Family Proteins in SARS-CoV-2 Infection
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DOI: 10.3390/biom11081126
Abstract: The recent pandemic we are experiencing caused by the coronavirus disease 2019 (COVID-19) has put the world’s population on the rack, with more than 191 million cases and more than 4.1 million deaths confirmed to… read more here.
Keywords: infection; bet family; sars cov; cov infection ... See more keywords