Non-canonical Transcriptional Consequences of BET Inhibition in Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological research"
DOI: 10.1016/j.phrs.2019.104508
Abstract: Inhibition of the bromo and extra-terminal domain (BET) protein family in preclinical studies has demonstrated that BET proteins are critical for cancer progression and important therapeutic targets. Downregulation of the MYC oncogene, CDK6, BCL2 and… read more here.
Keywords: inhibition; bet inhibition; non canonical; inhibition cancer ... See more keywords
Bromodomain and extra-terminal motif (BET) inhibition is synthetic lethal with loss of SMAD4 in colorectal cancer cells via restoring the loss of MYC repression
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-01580-w
Abstract: The tumor suppressor SMAD4 is frequently mutated in colorectal cancer (CRC). However, no effective targeted therapies exist for CRC with SMAD4 loss. Here, we employed a synthetic lethality drug screening in isogenic SMAD4+/+ and SMAD4−/−… read more here.
Keywords: bet inhibition; smad4; myc; loss ... See more keywords
BET inhibition prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjz114
Abstract: Cell culture K562 cells were acquired from ATCC and maintained in Isocove’s Modified Dulbecco’s Media (IMDM) (Life Technologies) containing 10% fetal bovine serum. Adherent STAG2null lines were detached for subculture using trypsin-EDTA (0.005% final concentration,… read more here.
Keywords: erg transcription; inhibition prevents; bet inhibition; prevents aberrant ... See more keywords
BET inhibition increases βIII-tubulin expression and sensitizes metastatic breast cancer in the brain to vinorelbine
Sign Up to like & getrecommendations! Published in 2020 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aax2879
Abstract: Combination of BET inhibitor and vinorelbine improves survival in preclinical models of brain metastases. BETting against brain metastases Brain metastases are a dreaded complication of many cancer types. Even for malignancies that are relatively treatable,… read more here.
Keywords: breast; breast cancer; bet inhibition; expression ... See more keywords
Loss of H3K27 trimethylation promotes radiotherapy resistance in medulloblastoma and induces an actionable vulnerability to BET inhibition.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-0871
Abstract: Medulloblastoma has been categorized into four subgroups based on genetic, epigenetic, and transcriptional profiling. Radiation is used for treating medulloblastoma regardless of the subgroup. A better understanding of the molecular pathways determining radiotherapy response could… read more here.
Keywords: medulloblastoma; resistance; resistance medulloblastoma; radiotherapy resistance ... See more keywords
Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-2072
Abstract: Mutations in the DNA mismatch repair gene MSH2 are causative of microsatellite instability (MSI) in multiple cancers. Here, we discovered that besides its well-established role in DNA repair, MSH2 exerts a novel epigenomic function in… read more here.
Keywords: cell adhesion; msh2; chromatin; bet inhibition ... See more keywords
Abstract 5173: BET inhibition reprograms pancreatic cancer associated fibroblasts to promote anti-tumor immunity
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5173
Abstract: BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the most malignant neoplasm of the pancreas, and is refractory to most therapeutic strategies, including immunotherapy. We have previously demonstrated that loss of CDKN2A in PDAC tumor cells promotes… read more here.
Keywords: tumor immunity; anti tumor; tumor; bet inhibition ... See more keywords
Abstract 6396: BET inhibition alleviates T-cell dysfunction in chronic lymphocytic leukemia
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6396
Abstract: Background: The chronic lymphocytic leukemia (CLL) tumor microenvironment (TME) is laden with hyporesponsive T-cells that permit disease persistence. Yet, redundant TME immunosuppressive mechanisms and epigenetic maintenance of T-cell exhaustion limit the efficacy of T-cell targeted… read more here.
Keywords: bet inhibition; cell; cll; expression ... See more keywords
BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells
Sign Up to like & getrecommendations! Published in 2018 at "Haematologica"
DOI: 10.3324/haematol.2017.181354
Abstract: Although inhibitors of bromodomain and extra terminal domain (BET) proteins show promising clinical activity in different hematologic malignancies, a systematic analysis of the consequences of pharmacological BET inhibition on healthy hematopoietic (stem) cells is urgently… read more here.
Keywords: bet inhibition; jq1; hematopoietic stem; stem ... See more keywords