BET protein inhibition promotes non-myeloid cell mediated neuroprotection after rodent spinal cord contusion
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2022.114035
Abstract: Spinal cord injuries (SCI) often lead to multiple neurological deficits as a result from the initial trauma and also the secondary damage that follows. Despite abundant preclinical data proposing anti-inflammatory therapies to minimize secondary injury… read more here.
Keywords: bet; inhibition; bet protein; bet proteins ... See more keywords
Apabetalone - BET protein inhibition in cardiovascular disease and Type 2 diabetes.
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DOI: 10.2217/fca-2020-0017
Abstract: Apabetalone is the first selective BET protein inhibitor in the field of cardiovascular diseases (CVD). BET proteins are epigenetic regulators that link upstream epigenetic modifications to downstream gene expression. Inhibition of BET proteins by apabetalone has… read more here.
Keywords: inhibition cardiovascular; apabetalone bet; bet protein; protein inhibition ... See more keywords
A Comprehensive Review of BET Protein Biochemistry, Physiology, and Pathological Roles
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DOI: 10.3389/fphar.2022.818891
Abstract: Epigenetic modifications, specifically acetylation of histone plays a decisive role in gene regulation and transcription of normal cellular mechanisms and pathological conditions. The bromodomain and extraterminal (BET) proteins (BRD2, BRD3, BRD4, and BRDT), being epigenetic… read more here.
Keywords: review; physiology; bet proteins; biochemistry ... See more keywords
Bromodomain and Extraterminal Domain (BET) Protein Inhibition Hinders Glioblastoma Progression by Inducing Autophagy-Dependent Differentiation
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DOI: 10.3390/ijms24087017
Abstract: Glioblastoma multiforme (GBM) is the most common and aggressive type of malignant primary brain tumor, and it is characterized by a high recurrence incidence and poor prognosis due to the presence of a highly heterogeneous… read more here.
Keywords: protein inhibition; domain bet; gbm; differentiation ... See more keywords