In vitro and in silico assessment of new beta amino ketones with antiplasmodial activity
Sign Up to like & getrecommendations! Published in 2022 at "Revista da Sociedade Brasileira de Medicina Tropical"
DOI: 10.1590/0037-8682-0590-2022
Abstract: ABSTRACT Background: Based on the current need for new drugs against malaria, our study evaluated eight beta amino ketones in silico and in vitro for potential antimalarial activity. Methods: Using the Brazilian Malaria Molecular Targets… read more here.
Keywords: antiplasmodial activity; amino ketones; beta amino;
Co-Delivery of p53 Restored and E7 Targeted Nucleic Acids by Poly (Beta-Amino Ester) Complex Nanoparticles for the Treatment of HPV Related Cervical Lesions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.826771
Abstract: The p53 gene has the highest mutation frequency in tumors, and its inactivation can lead to malignant transformation, such as cell cycle arrest and apoptotic inhibition. Persistent high-risk human papillomavirus (HR-HPV) infection is the leading… read more here.
Keywords: beta amino; hpv; p53; treatment ... See more keywords
Differential Oligomerization of Alpha versus Beta Amino Acids and Hydroxy Acids in Abiotic Proto-Peptide Synthesis Reactions
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12020265
Abstract: The origin of biopolymers is a central question in origins of life research. In extant life, proteins are coded linear polymers made of a fixed set of twenty alpha-L-amino acids. It is likely that the… read more here.
Keywords: amino acids; beta amino; hydroxy acids; alpha versus ... See more keywords