Melatonin binds with high affinity and specificity to beta‐amyloid: LC‐MS provides insight into Alzheimer’s disease treatment
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13279
Abstract: To study the potential relationship between melatonin and beta‐amyloid (Abeta), we established a liquid chromatography–mass spectrometry (LC‐MS) method to quantitatively analyze melatonin, deuterated isotopes (melatonin‐D4), and internal standard 6‐iodo‐2‐(4'‐dimethylamino‐) phenyl‐imidazo(1,2) pyridine (IMPY) under positive (+)… read more here.
Keywords: melatonin; alzheimer disease; beta amyloid; affinity ... See more keywords
[18F] AV-1451 uptake in corticobasal syndrome: the influence of beta-amyloid and clinical presentation
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DOI: 10.1007/s00415-018-8815-x
Abstract: Corticobasal syndrome (CBS) is a phenotypic manifestation of diverse pathologies, including Alzheimer’s disease and 4-repeat tauopathies. Predicting pathology in CBS is unreliable and, hence, molecular neuroimaging may prove to be useful. The aim of this… read more here.
Keywords: 1451 uptake; cbs; beta amyloid; 18f 1451 ... See more keywords
Ultrastructural Alterations in Granular Neurons of the Dentate Fascia Caused by Intrahippocampal Injection of Beta-Amyloid 1-42
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DOI: 10.1007/s10517-020-04806-9
Abstract: The deposition of beta-amyloid (Aβ) in the brain is detected in Alzheimer’s disease and during ageing. Until now, ultrastructural studies of changes caused by Aβ in the dentate gyrus are very scarce. The effects of… read more here.
Keywords: ultrastructural alterations; alterations granular; dentate gyrus; beta amyloid ... See more keywords
Exploring the relationship between physical activity, beta-amyloid and tau: A narrative review
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DOI: 10.1016/j.arr.2019.01.003
Abstract: Several prospective cohort studies have reported an association between higher levels of physical activity and decreased risk of cognitive decline and dementia, years later. To support physical activity as a preventative measure against dementia, including… read more here.
Keywords: amyloid tau; relationship physical; beta amyloid; physical activity ... See more keywords
Intracisternal injection of beta-amyloid seeds promotes cerebral amyloid angiopathy
Sign Up to like & getrecommendations! Published in 2020 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.07.038
Abstract: Beta amyloid (Aβ) is a key component of parenchymal Aβ plaques and vascular Aβ fibrils, which lead to cerebral amyloid angiopathy (CAA) in Alzheimer's disease (AD). Recent studies have revealed that Aβ contained in the… read more here.
Keywords: amyloid angiopathy; cerebral amyloid; amyloid; beta amyloid ... See more keywords
Relevance of electroencephalogram assessment in amyloid and tau pathology in rat
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DOI: 10.1016/j.bbr.2018.10.026
Abstract: HighlightsThe rats express in hippocampus beta‐amyloid deposits and phosphorylated tau.On the 3rd month, a working memory impairment is observed by Morris water maze test.On the 3rd week, an overall decrease of the EEG bands power… read more here.
Keywords: amyloid tau; tau; tau pathology; beta amyloid ... See more keywords
Low-level laser therapy for beta amyloid toxicity in rat hippocampus
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2016.10.003
Abstract: Beta amyloid (Aβ) is well accepted to play a central role in the pathogenesis of Alzheimer's disease (AD). The present work evaluated the therapeutic effects of low-level laser irradiation (LLI) on Aβ-induced neurotoxicity in rat… read more here.
Keywords: beta amyloid; pathology; suppressed induced; level laser ... See more keywords
Alzheimer's disease and late-onset epilepsy of unknown origin: two faces of beta amyloid pathology
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2018.09.006
Abstract: Although amyloid pathology plays a role in epilepsy, little is known about the relationship between beta amyloid and progression to Alzheimer's disease (AD) among patients with late-onset epilepsy of unknown origin (LOEU). This multicenter, observational,… read more here.
Keywords: late onset; alzheimer disease; onset epilepsy; beta amyloid ... See more keywords
Is there a specific memory signature associated with Aβ-PET positivity in patients with amnestic mild cognitive impairment?
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DOI: 10.1016/j.neurobiolaging.2019.01.017
Abstract: Amnestic mild cognitive impairment (aMCI) is a clinical entity with various potential etiologies including but not limited to Alzheimer's disease. We examined whether a positive ([18F]Florbetapir) beta amyloid positron emission tomography scan, supporting underlying Alzheimer's… read more here.
Keywords: amnestic mild; memory; beta amyloid; cognitive impairment ... See more keywords
Molecular imaging of beta-amyloid deposition in late-life depression
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DOI: 10.1016/j.neurobiolaging.2021.01.002
Abstract: Late-life depression (LLD) is associated with an increased risk of all-cause dementia and may involve Alzheimer's disease pathology. Twenty-one LLD patients who met the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, criteria for… read more here.
Keywords: depression; lld patients; life depression; beta amyloid ... See more keywords
Effect of an Intracerebroventricular Injection of Aggregated Beta-amyloid (1–42) on Daily Rhythms of Oxidative Stress Parameters in the Prefrontal Cortex
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DOI: 10.1016/j.neuroscience.2020.08.016
Abstract: Accumulation of amyloid peptides in the brain plays a key role in the pathogenesis of Alzheimer's disease (AD). Aggregated beta-amyloid (Aβ) peptide increases intracellular reactive oxygen species associated to a deficient antioxidant defense system. Prefrontal… read more here.
Keywords: beta amyloid; injection; aggregated beta; prefrontal cortex ... See more keywords